Component

Menthol

Menthol. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.

    Capsaicin → Human oral burn from vanillyl butyl ether, cinnamaldehyde and ethanol source_derived_draftungraded
    Experimental context and source evidence
    dose
    6 ppm capsaicin rinse twice daily
    duration
    17 days
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Healthy human volunteers
    limitations
    The result shows selective sensory adaptation, not shared binding to one receptor for every stimulus.
    nutrient_topic
    Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Capsaicin
    organism
    Healthy human volunteers
    plain_language
    Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.
    primary_references
    Inducible desensitization to capsaicin with repeated low-dose exposure in human volunteers. (2024). https://pubmed.ncbi.nlm.nih.gov/38135109/ DOI: 10.1016/j.physbeh.2023.114447
    route
    Oral rinse
    tissue
    Cross-stimulus oral sensory ratings

    Capsaicin: mechanism of action and interactions (2026-09-20) · lines 77–86

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Healthy human volunteers · source_derived_draft · unverified_draft

    ## capsaicin-human-cross-desensitization Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change. Model/species: Healthy human volunteers Tissue/system: Cross-stimulus oral sensory ratings Exposure: 6 ppm capsaicin rinse twice daily Route: Oral rinse Duration: 17 days Limits: The result shows selective sensory adaptation, not shared binding to one receptor for every stimulus. Primary reference: Inducible desensitization to capsaicin with repeated low-dose exposure in human volunteers. (2024). https://pubmed.ncbi.nlm.nih.gov/38135109/ DOI: 10.1016/j.physbeh.2023.114447 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  2. Cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice showed profoundly diminished responses to cold, demonstrating an essential and predominant role for TRPM8 in thermosensation over a wide range of cold temperatures.

    Transient receptor potential melastatin 8 / TRPM8 cold and menthol receptor → Cold-evoked firing of primary afferent sensory neurons source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/17538622.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300", "start_char": 0, "end_char": 1451, "text_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300"}
    experimental_model
    TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour
    exposure
    Ambient cooling below about 26 degrees C; menthol as a chemical agonist
    limitations
    A genetic loss-of-function study. TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse
    plain_language
    One ion channel is what actually reports cold to the nervous system.
    primary_references
    [cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. (2007). https://pubmed.ncbi.nlm.nih.gov/17538622/ DOI: 10.1038/nature05910
    tissue_or_cell_type
    Primary afferent sensory neurons

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 65–76

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour · source_derived_draft · unverified_draft

    ### cold-trpm8-cold-detector Cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice showed profoundly diminished responses to cold, demonstrating an essential and predominant role for TRPM8 in thermosensation over a wide range of cold temperatures. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: One ion channel is what actually reports cold to the nervous system. organism: Mouse tissue_or_cell_type: Primary afferent sensory neurons experimental_model: TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour limitations: A genetic loss-of-function study. TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector. exposure: Ambient cooling below about 26 degrees C; menthol as a chemical agonist evidence_span: {"source_cache": "artifacts/cold-research/17538622.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300", "start_char": 0, "end_char": 1451, "text_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300"} [cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. (2007). https://pubmed.ncbi.nlm.nih.gov/17538622/ DOI: 10.1038/nature05910
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards