Component
Cold-evoked firing of primary afferent sensory neurons
Cold-evoked firing of primary afferent sensory neurons. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice showed profoundly diminished responses to cold, demonstrating an essential and predominant role for TRPM8 in thermosensation over a wide range of cold temperatures.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/17538622.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300", "start_char": 0, "end_char": 1451, "text_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300"}
- experimental_model
- TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour
- exposure
- Ambient cooling below about 26 degrees C; menthol as a chemical agonist
- limitations
- A genetic loss-of-function study. TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Mouse
- plain_language
- One ion channel is what actually reports cold to the nervous system.
- primary_references
- [cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. (2007). https://pubmed.ncbi.nlm.nih.gov/17538622/ DOI: 10.1038/nature05910
- tissue_or_cell_type
- Primary afferent sensory neurons
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 65–76
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour · source_derived_draft · unverified_draft
### cold-trpm8-cold-detector Cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice showed profoundly diminished responses to cold, demonstrating an essential and predominant role for TRPM8 in thermosensation over a wide range of cold temperatures. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: One ion channel is what actually reports cold to the nervous system. organism: Mouse tissue_or_cell_type: Primary afferent sensory neurons experimental_model: TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour limitations: A genetic loss-of-function study. TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector. exposure: Ambient cooling below about 26 degrees C; menthol as a chemical agonist evidence_span: {"source_cache": "artifacts/cold-research/17538622.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300", "start_char": 0, "end_char": 1451, "text_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300"} [cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. (2007). https://pubmed.ncbi.nlm.nih.gov/17538622/ DOI: 10.1038/nature05910
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.