{"id":"6c2aab26-94b3-5d66-aea2-d588d617692b","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-human-cross-desensitization","predicate":"cross_desensitizes","statement":"Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"c2a2c70e-6c38-597e-9150-efc492639105","mechanism_event_label":"Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.","subject":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"object":{"id":"388f3fd5-4da1-55e4-a05b-cf70701982ac","slug":"human-oral-irritant-burn","display_name":"Human oral burn from vanillyl butyl ether, cinnamaldehyde and ethanol","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c2a2c70e-6c38-597e-9150-efc492639105","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-human-cross-desensitization-event","event_type":"observed_relationship","label":"Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.","description":"Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"388f3fd5-4da1-55e4-a05b-cf70701982ac","slug":"human-oral-irritant-burn","display_name":"Human oral burn from vanillyl butyl ether, cinnamaldehyde and ethanol","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53560067-da1d-54f0-b055-741a3297114a","slug":"cinnamaldehyde","display_name":"Cinnamaldehyde","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"c027a2c4-e0af-5f6b-8190-7a107aad1a05","slug":"menthol","display_name":"Menthol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6 ppm capsaicin rinse twice daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"17 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The result shows selective sensory adaptation, not shared binding to one receptor for every stimulus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Repeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inducible desensitization to capsaicin with repeated low-dose exposure in human volunteers. (2024). https://pubmed.ncbi.nlm.nih.gov/38135109/ DOI: 10.1016/j.physbeh.2023.114447","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral rinse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cross-stimulus oral sensory ratings","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"505d6509-6646-5283-be6b-887e63ea9ff2","evidence_kind":"source_excerpt","locator":"Lines 77-86","start_line":77,"end_line":86,"excerpt":"## capsaicin-human-cross-desensitization\nRepeated capsaicin rinsing reduced burn from vanillyl butyl ether, cinnamaldehyde and ethanol, while menthol cooling and sucrose sweetness did not change.\nModel/species: Healthy human volunteers\nTissue/system: Cross-stimulus oral sensory ratings\nExposure: 6 ppm capsaicin rinse twice daily\nRoute: Oral rinse\nDuration: 17 days\nLimits: The result shows selective sensory adaptation, not shared binding to one receptor for every stimulus.\nPrimary reference: Inducible desensitization to capsaicin with repeated low-dose exposure in human volunteers. (2024). https://pubmed.ncbi.nlm.nih.gov/38135109/ DOI: 10.1016/j.physbeh.2023.114447\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Healthy human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"883c8afb-af48-5561-ae3b-00d4f3c26752","stable_key":"import-49fecf36-4958-5f15-8c78-9a68cba50763","title":"Capsaicin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"ea5c8dc49ffdfcec3f5542fed8be406c4af37873b76416910f88a743b733466e","revision_id":"79e49bef-520e-5503-ad2e-7de89ad236cf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}