Component
Survival following early copper treatment in Menkes disease
Survival following early copper treatment in Menkes disease. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Survival was 92% in the twelve early-treated infants at median 4.6-year follow-up versus 13% in the historical late-treatment group at median 1.8 years.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/18256395.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e855a0286cb633432b654005d756aa1e887ddace4f2a4dc5fee6cca518d895ce", "start_char": 0, "end_char": 2319, "text_sha256": "e855a0286cb633432b654005d756aa1e887ddace4f2a4dc5fee6cca518d895ce"}
- experimental_model
- Early-treatment Menkes cohort with historical comparison and functional genotyping
- exposure
- Copper injections begun by 22 days in twelve infants; comparison with fifteen later-treated historical patients
- limitations
- Not randomized; survival follow-up differed between cohorts. Genotype and residual function influenced outcome, so results cannot be generalized to every ATP7A variant.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human infants
- plain_language
- Early treatment was associated with much better survival in this cohort, with important comparison limits.
- primary_references
- [copper-p18256395] Neonatal diagnosis and treatment of Menkes disease. (2008). https://pubmed.ncbi.nlm.nih.gov/18256395/ DOI: 10.1056/nejmoa070613
- tissue_or_cell_type
- Survival and neurodevelopment
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1443–1454
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Early-treatment Menkes cohort with historical comparison and functional genotyping · source_derived_draft · unverified_draft
### copper-menkes-early-survival Survival was 92% in the twelve early-treated infants at median 4.6-year follow-up versus 13% in the historical late-treatment group at median 1.8 years. Condition category: machinery_impairment nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Early treatment was associated with much better survival in this cohort, with important comparison limits. organism: Human infants tissue_or_cell_type: Survival and neurodevelopment experimental_model: Early-treatment Menkes cohort with historical comparison and functional genotyping limitations: Not randomized; survival follow-up differed between cohorts. Genotype and residual function influenced outcome, so results cannot be generalized to every ATP7A variant. exposure: Copper injections begun by 22 days in twelve infants; comparison with fifteen later-treated historical patients evidence_span: {"source_cache": "artifacts/copper-research/18256395.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e855a0286cb633432b654005d756aa1e887ddace4f2a4dc5fee6cca518d895ce", "start_char": 0, "end_char": 2319, "text_sha256": "e855a0286cb633432b654005d756aa1e887ddace4f2a4dc5fee6cca518d895ce"} [copper-p18256395] Neonatal diagnosis and treatment of Menkes disease. (2008). https://pubmed.ncbi.nlm.nih.gov/18256395/ DOI: 10.1056/nejmoa070613
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.