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Genotype and residual function influenced outcome, so results cannot be generalized to every ATP7A variant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human infants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Early treatment was associated with much better survival in this cohort, with important comparison limits.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p18256395] Neonatal diagnosis and treatment of Menkes disease. (2008). https://pubmed.ncbi.nlm.nih.gov/18256395/ DOI: 10.1056/nejmoa070613","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Survival and neurodevelopment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a907369b-abb6-512b-b497-278fdf6ba9e7","evidence_kind":"source_excerpt","locator":"Lines 1443-1454","start_line":1443,"end_line":1454,"excerpt":"### copper-menkes-early-survival\nSurvival was 92% in the twelve early-treated infants at median 4.6-year follow-up versus 13% in the historical late-treatment group at median 1.8 years.\nCondition category: machinery_impairment\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Early treatment was associated with much better survival in this cohort, with important comparison limits.\norganism: Human infants\ntissue_or_cell_type: Survival and neurodevelopment\nexperimental_model: Early-treatment Menkes cohort with historical comparison and functional genotyping\nlimitations: Not randomized; survival follow-up differed between cohorts. Genotype and residual function influenced outcome, so results cannot be generalized to every ATP7A variant.\nexposure: Copper injections begun by 22 days in twelve infants; comparison with fifteen later-treated historical patients\nevidence_span: {\"source_cache\": \"artifacts/copper-research/18256395.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e855a0286cb633432b654005d756aa1e887ddace4f2a4dc5fee6cca518d895ce\", \"start_char\": 0, \"end_char\": 2319, \"text_sha256\": \"e855a0286cb633432b654005d756aa1e887ddace4f2a4dc5fee6cca518d895ce\"}\n[copper-p18256395] Neonatal diagnosis and treatment of Menkes disease. 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