Component
Circadian onset of endogenous melatonin secretion
Circadian onset of endogenous melatonin secretion. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Post-treatment dim-light melatonin onset did not differ significantly between groups in the measured subset of 43 patients.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/29912983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c", "start_char": 0, "end_char": 3360, "text_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c"}
- experimental_model
- Randomized double-blind placebo-controlled trial
- exposure
- 0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks
- limitations
- Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- 116 people with delayed sleep-wake phase disorder and delayed endogenous phase
- plain_language
- Earlier sleep in this trial did not prove a measured shift in the circadian hormone onset.
- primary_references
- [melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587
- tissue_or_cell_type
- Sleep timing and daytime impairment
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 955–966
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### melatonin-dswpd-phase-null Post-treatment dim-light melatonin onset did not differ significantly between groups in the measured subset of 43 patients. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Earlier sleep in this trial did not prove a measured shift in the circadian hormone onset. organism: 116 people with delayed sleep-wake phase disorder and delayed endogenous phase tissue_or_cell_type: Sleep timing and daytime impairment experimental_model: Randomized double-blind placebo-controlled trial limitations: Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested. exposure: 0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks evidence_span: {"source_cache": "artifacts/melatonin-research/29912983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c", "start_char": 0, "end_char": 3360, "text_sha256": "fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c"} [melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587
Complete structured claim and evidenceRoom light delayed measured melatonin onset in 99% of participants relative to dim light.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/melatonin-research/21193540.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23", "start_char": 0, "end_char": 1666, "text_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23"}
- experimental_model
- Controlled-light profiles analyzed retrospectively
- exposure
- Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours
- limitations
- Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- 116 healthy adults aged 18-30
- plain_language
- The conditions during measurement can change when the night signal appears.
- primary_references
- [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098
- tissue_or_cell_type
- Circulating melatonin under different light conditions
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 877–888
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled-light profiles analyzed retrospectively · source_derived_draft · unverified_draft
### melatonin-light-onset Room light delayed measured melatonin onset in 99% of participants relative to dim light. Condition category: biomarker_context nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The conditions during measurement can change when the night signal appears. organism: 116 healthy adults aged 18-30 tissue_or_cell_type: Circulating melatonin under different light conditions experimental_model: Controlled-light profiles analyzed retrospectively limitations: Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency. exposure: Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours evidence_span: {"source_cache": "artifacts/melatonin-research/21193540.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23", "start_char": 0, "end_char": 1666, "text_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23"} [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.