{"id":"407f2d6e-187b-5cf2-aa04-a3ded0cf4eaa","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-dswpd-phase-null","predicate":"did_not_significantly_shift_between_groups","statement":"Post-treatment dim-light melatonin onset did not differ significantly between groups in the measured subset of 43 patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"29d2436b-20a4-5b75-96cc-7897c4b88fdc","mechanism_event_label":"Earlier sleep in this trial did not prove a measured shift in the circadian hormone onset.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"f5e40e82-336d-5dc1-a892-f2f77181deba","slug":"melatonin-circadian-onset","display_name":"Circadian onset of endogenous melatonin secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"29d2436b-20a4-5b75-96cc-7897c4b88fdc","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-dswpd-phase-null-event","event_type":"observed_intervention","label":"Earlier sleep in this trial did not prove a measured shift in the circadian hormone onset.","description":"Post-treatment dim-light melatonin onset did not differ significantly between groups in the measured subset of 43 patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f5e40e82-336d-5dc1-a892-f2f77181deba","slug":"melatonin-circadian-onset","display_name":"Circadian onset of endogenous melatonin secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/29912983.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\", \"start_char\": 0, \"end_char\": 3360, \"text_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"116 people with delayed sleep-wake phase disorder and delayed endogenous phase","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Earlier sleep in this trial did not prove a measured shift in the circadian hormone onset.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Sleep timing and daytime impairment","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fcee90c5-b829-5cab-b18c-f0b427398d25","evidence_kind":"source_excerpt","locator":"Lines 955-966","start_line":955,"end_line":966,"excerpt":"### melatonin-dswpd-phase-null\nPost-treatment dim-light melatonin onset did not differ significantly between groups in the measured subset of 43 patients.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Earlier sleep in this trial did not prove a measured shift in the circadian hormone onset.\norganism: 116 people with delayed sleep-wake phase disorder and delayed endogenous phase\ntissue_or_cell_type: Sleep timing and daytime impairment\nexperimental_model: Randomized double-blind placebo-controlled trial\nlimitations: Selected delayed-phase population, not all people reporting insomnia. Post-treatment DLMO subset did not differ significantly; long-term effects were not tested.\nexposure: 0.5 mg fast-release one hour before desired bedtime, plus behavioral scheduling in both arms, four weeks\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/29912983.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\", \"start_char\": 0, \"end_char\": 3360, \"text_sha256\": \"fd415c3cd95238c53759d8e28260e8e33e934391d3e2e160074c56e18613cb4c\"}\n[melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587","model_system":"Randomized double-blind placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p29912983] Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29912983/ DOI: 10.1371/journal.pmed.1002587","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}