Component
Human matrilin-2 / MATN2
Human matrilin-2 / MATN2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MATN2 was identified as a primary SXR target responsive to vitamin K2 and rifampicin in osteoblastic cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/16606623.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a2c0e756d507fd0cef9dea48e3eedc193084378509ec54bce2c097f8491e4b45", "start_char": 0, "end_char": 1266, "text_sha256": "a2c0e756d507fd0cef9dea48e3eedc193084378509ec54bce2c097f8491e4b45"}
- experimental_model
- Microarray, qPCR and gain/loss-of-function studies
- exposure
- Vitamin K2 and rifampicin/SXR stimulation
- limitations
- Cell transcription and collagen accumulation; not a human fracture study.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Human osteoblastic MG63 cells
- plain_language
- The receptor connects to a separately identifiable downstream gene.
- primary_references
- [k2-p16606623] Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. (2006). https://pubmed.ncbi.nlm.nih.gov/16606623/ DOI: 10.1074/jbc.m600896200
- tissue_or_cell_type
- Extracellular-matrix gene regulation
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 734–745
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microarray, qPCR and gain/loss-of-function studies · source_derived_draft · unverified_draft
### k2-sxr-matn2 MATN2 was identified as a primary SXR target responsive to vitamin K2 and rifampicin in osteoblastic cells. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor connects to a separately identifiable downstream gene. organism: Human osteoblastic MG63 cells tissue_or_cell_type: Extracellular-matrix gene regulation experimental_model: Microarray, qPCR and gain/loss-of-function studies limitations: Cell transcription and collagen accumulation; not a human fracture study. exposure: Vitamin K2 and rifampicin/SXR stimulation evidence_span: {"source_cache": "artifacts/k2-research/16606623.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a2c0e756d507fd0cef9dea48e3eedc193084378509ec54bce2c097f8491e4b45", "start_char": 0, "end_char": 1266, "text_sha256": "a2c0e756d507fd0cef9dea48e3eedc193084378509ec54bce2c097f8491e4b45"} [k2-p16606623] Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. (2006). https://pubmed.ncbi.nlm.nih.gov/16606623/ DOI: 10.1074/jbc.m600896200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.