Component
Viability of the 2017 mammalian allicin cell-line panel
Viability of the 2017 mammalian allicin cell-line panel. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Direct allicin exposure reduced mammalian-cell viability or proliferation in a concentration- and cell-type-dependent manner.
Experimental context and source evidence
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_contrast
- {"intervention": "Allicin concentration series", "comparator": "Matched untreated cells in each model", "endpoint": "Direct allicin exposure reduced mammalian-cell viability or proliferation in a concentration- and cell-type-dependent manner.", "effect_direction": "mixed", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human A549/HUVEC/HT29/MCF7 and mouse 3T3; separate viability, proliferation and apoptosis assays.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Separate species and endpoints; no cancer-selective clinical efficacy or direct measurement of every GSH species.
- plain_language
- Direct allicin exposure reduced mammalian-cell viability or proliferation in a concentration- and cell-type-dependent manner.
- primary_references
- The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines. | 2016 | DOI 10.3390/antiox6010001 | PMID 28035949 | https://pubmed.ncbi.nlm.nih.gov/28035949/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC5384165/ | https://doi.org/10.3390/antiox6010001
- source_locator
- Reviewed reference lines 53-53; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 53–53
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human A549/HUVEC/HT29/MCF7 and mouse 3T3; separate viability, proliferation and apoptosis assays. · source_derived_draft · unverified_draft
**Mammalian injury is context-dependent.** Allicin reduced viability or proliferation and altered thiol-associated fluorescence in a panel including human A549, HUVEC, HT29, and MCF7 cells and mouse 3T3 cells. Sensitivity and apoptotic responses differed. Fluorescence changes are not a complete measurement of every glutathione species. Thiol reactivity does not guarantee selective toxicity to microbes or cancer cells. [Gruhlke 2017](https://pmc.ncbi.nlm.nih.gov/articles/PMC5384165/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.