Component
Major adverse kidney event within 30 days / MAKE30
Major adverse kidney event within 30 days / MAKE30. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MAKE30 occurred in 14.3% with balanced crystalloids versus 15.4% with saline (P=0.04).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/29485925.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "10dfa6509546c1ed6e3ef5ebf45e595574e58e70aca47dbb2bd372c71ffa333a", "start_char": 0, "end_char": 1901, "text_sha256": "10dfa6509546c1ed6e3ef5ebf45e595574e58e70aca47dbb2bd372c71ffa333a"}
- experimental_model
- SMART pragmatic cluster-randomized crossover
- exposure
- Balanced crystalloids versus saline
- limitations
- Composite primary endpoint; mortality and separate renal components were not individually significant. Not chloride-only randomization.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- 15,802 critically ill adults
- plain_language
- One large trial favored balanced fluid for a combined kidney-and-death endpoint.
- primary_references
- [chloride-p29485925] Balanced Crystalloids versus Saline in Critically Ill Adults. (2018). https://pubmed.ncbi.nlm.nih.gov/29485925/ DOI: 10.1056/nejmoa1711584
- tissue_or_cell_type
- Five ICUs at one academic center
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 1004–1015
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SMART pragmatic cluster-randomized crossover · source_derived_draft · unverified_draft
### chloride-smart-composite MAKE30 occurred in 14.3% with balanced crystalloids versus 15.4% with saline (P=0.04). Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: One large trial favored balanced fluid for a combined kidney-and-death endpoint. organism: 15,802 critically ill adults tissue_or_cell_type: Five ICUs at one academic center experimental_model: SMART pragmatic cluster-randomized crossover limitations: Composite primary endpoint; mortality and separate renal components were not individually significant. Not chloride-only randomization. exposure: Balanced crystalloids versus saline evidence_span: {"source_cache": "artifacts/chloride-research/29485925.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "10dfa6509546c1ed6e3ef5ebf45e595574e58e70aca47dbb2bd372c71ffa333a", "start_char": 0, "end_char": 1901, "text_sha256": "10dfa6509546c1ed6e3ef5ebf45e595574e58e70aca47dbb2bd372c71ffa333a"} [chloride-p29485925] Balanced Crystalloids versus Saline in Critically Ill Adults. (2018). https://pubmed.ncbi.nlm.nih.gov/29485925/ DOI: 10.1056/nejmoa1711584
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.