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(2018). https://pubmed.ncbi.nlm.nih.gov/29485925/ DOI: 10.1056/nejmoa1711584","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Five ICUs at one academic center","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"621bb11e-6414-5d16-8232-bc90cb9bc966","evidence_kind":"source_excerpt","locator":"Lines 1004-1015","start_line":1004,"end_line":1015,"excerpt":"### chloride-smart-composite\nMAKE30 occurred in 14.3% with balanced crystalloids versus 15.4% with saline (P=0.04).\nCondition category: normal\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One large trial favored balanced fluid for a combined kidney-and-death endpoint.\norganism: 15,802 critically ill adults\ntissue_or_cell_type: Five ICUs at one academic center\nexperimental_model: SMART pragmatic cluster-randomized crossover\nlimitations: Composite primary endpoint; mortality and separate renal components were not individually significant. 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