Component
Rate of major congenital malformation
Rate of major congenital malformation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Among 192 pregnancies exposed to mebendazole and followed prospectively, 71.5% with first-trimester exposure, there was no increase in the rate of major malformations against a matched control group counselled for non-teratogenic exposure, 3.3% against 1.7%, though there was a higher rate of elective termination in the exposed group at 11.5% against 1.6%, and the authors conclude that mebendazole does not represent a major teratogenic risk in humans at the doses commonly used for pinworm.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/12548230.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08e6e832094453e69ff88f5daeb82e145cd70180f68658be2c0c30b686fd2fad", "start_char": 0, "end_char": 1183, "text_sha256": "08e6e832094453e69ff88f5daeb82e145cd70180f68658be2c0c30b686fd2fad"}
- experimental_model
- Prospective controlled cohort of 192 pregnancies followed by the Israeli Teratogen Information Service
- exposure
- Mebendazole exposure in pregnancy, 71.5% in the first trimester, against a matched non-teratogenic control group
- limitations
- A prospective cohort of 192 pregnancies, which can exclude a large risk but not a small one, at pinworm doses rather than the high doses used for echinococcosis or oncology.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Human
- plain_language
- In nearly two hundred pregnancies there was no excess of birth defects, though many more of these pregnancies were ended by choice.
- primary_references
- [mbz-p12548230] Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study. (2003). https://pubmed.ncbi.nlm.nih.gov/12548230/ DOI: 10.1067/mob.2003.79
- tissue_or_cell_type
- Pregnancy outcome
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Prospective controlled cohort of 192 pregnancies followed by the Israeli Teratogen Information Service · source_derived_draft · unverified_draft
### mbz-no-major-teratogenic-signal Among 192 pregnancies exposed to mebendazole and followed prospectively, 71.5% with first-trimester exposure, there was no increase in the rate of major malformations against a matched control group counselled for non-teratogenic exposure, 3.3% against 1.7%, though there was a higher rate of elective termination in the exposed group at 11.5% against 1.6%, and the authors conclude that mebendazole does not represent a major teratogenic risk in humans at the doses commonly used for pinworm. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: In nearly two hundred pregnancies there was no excess of birth defects, though many more of these pregnancies were ended by choice. organism: Human tissue_or_cell_type: Pregnancy outcome experimental_model: Prospective controlled cohort of 192 pregnancies followed by the Israeli Teratogen Information Service limitations: A prospective cohort of 192 pregnancies, which can exclude a large risk but not a small one, at pinworm doses rather than the high doses used for echinococcosis or oncology. exposure: Mebendazole exposure in pregnancy, 71.5% in the first trimester, against a matched non-teratogenic control group evidence_span: {"source_cache": "artifacts/mebendazole-research/12548230.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08e6e832094453e69ff88f5daeb82e145cd70180f68658be2c0c30b686fd2fad", "start_char": 0, "end_char": 1183, "text_sha256": "08e6e832094453e69ff88f5daeb82e145cd70180f68658be2c0c30b686fd2fad"} [mbz-p12548230] Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study. (2003). https://pubmed.ncbi.nlm.nih.gov/12548230/ DOI: 10.1067/mob.2003.79
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.