{"id":"dd2030c1-7998-5edc-b362-49903cfd3c47","stable_key":"f2ec2007-88ff-5a96-a73b-8b5085e9cea9:mbz-no-major-teratogenic-signal","predicate":"preserves_measured_pool","statement":"Among 192 pregnancies exposed to mebendazole and followed prospectively, 71.5% with first-trimester exposure, there was no increase in the rate of major malformations against a matched control group counselled for non-teratogenic exposure, 3.3% against 1.7%, though there was a higher rate of elective termination in the exposed group at 11.5% against 1.6%, and the authors conclude that mebendazole does not represent a major teratogenic risk in humans at the doses commonly used for pinworm.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f841a005-9c8e-5025-bb0a-33d490beeabc","mechanism_event_label":"In nearly two hundred pregnancies there was no excess of birth defects, though many more of these pregnancies were ended by choice.","subject":{"id":"f8582a13-fc2e-5127-a61f-5b0594e54069","slug":"mebendazole","display_name":"Mebendazole","entity_type_key":"drug"},"object":{"id":"58e51b86-07b7-58a3-9fb6-b6511e57d607","slug":"major-malformation-rate","display_name":"Rate of major congenital malformation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f841a005-9c8e-5025-bb0a-33d490beeabc","stable_key":"f2ec2007-88ff-5a96-a73b-8b5085e9cea9:mbz-no-major-teratogenic-signal-event","event_type":"observed_intervention","label":"In nearly two hundred pregnancies there was no excess of birth defects, though many more of these pregnancies were ended by choice.","description":"Among 192 pregnancies exposed to mebendazole and followed prospectively, 71.5% with first-trimester exposure, there was no increase in the rate of major malformations against a matched control group counselled for non-teratogenic exposure, 3.3% against 1.7%, though there was a higher rate of elective termination in the exposed group at 11.5% against 1.6%, and the authors conclude that mebendazole does not represent a major teratogenic risk in humans at the doses commonly used for pinworm.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c7f3747a-2371-54da-8c62-d79c855399ab","slug":"developmental-toxicity","display_name":"Developmental toxicity","entity_type_key":"cellular_process"},"role":"assessed_outcome","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f8582a13-fc2e-5127-a61f-5b0594e54069","slug":"mebendazole","display_name":"Mebendazole","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58e51b86-07b7-58a3-9fb6-b6511e57d607","slug":"major-malformation-rate","display_name":"Rate of major congenital malformation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mebendazole-research/12548230.abstract.txt\", \"locator\": \"Indexed abstract; 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