Component
Macrocytic anemia
Independently recorded substance, clinical endpoint or assay readout. Claims retain study-specific population and measurement context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Macrocytic anemia was documented after 469 days of restriction in the self-experiment.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations.
- exposure
- Prolonged severe folate restriction, major energy restriction/weight loss, and multiple other nutrient supplements; replete diet plus folic acid during recovery.
- limitations
- One subject, calorie restriction and multiple co-supplements; cannot calculate a population time-to-anemia distribution.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- The red-cell disorder appeared after the blood folate changes.
- primary_references
- [fol-golding2014] Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops (2014). https://pubmed.ncbi.nlm.nih.gov/25332850/ DOI: 10.1186/2193-1801-3-442
- tissue_or_cell_type
- Human blood or whole-person clinical endpoints
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1517–1527
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations. · source_derived_draft · unverified_draft
### fol-severe-macrocytic-anemia Macrocytic anemia was documented after 469 days of restriction in the self-experiment. Condition category: nutrient_deficiency nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The red-cell disorder appeared after the blood folate changes. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person clinical endpoints experimental_model: Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations. limitations: One subject, calorie restriction and multiple co-supplements; cannot calculate a population time-to-anemia distribution. exposure: Prolonged severe folate restriction, major energy restriction/weight loss, and multiple other nutrient supplements; replete diet plus folic acid during recovery. [fol-golding2014] Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops (2014). https://pubmed.ncbi.nlm.nih.gov/25332850/ DOI: 10.1186/2193-1801-3-442
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.