{"id":"19a0f41d-df3a-5bcf-8833-abf64d1ce2c4","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-severe-macrocytic-anemia","predicate":"prolonged_restriction_preceded_macrocytic_anemia","statement":"Macrocytic anemia was documented after 469 days of restriction in the self-experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c19fb422-9e91-5c9b-92ca-1c0e61dbb3f4","mechanism_event_label":"The red-cell disorder appeared after the blood folate changes.","subject":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"object":{"id":"2a1d1133-ab9b-5643-b83f-833699c95615","slug":"macrocytic-anemia","display_name":"Macrocytic anemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c19fb422-9e91-5c9b-92ca-1c0e61dbb3f4","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-severe-macrocytic-anemia-event","event_type":"observed_intervention","label":"The red-cell disorder appeared after the blood folate changes.","description":"Macrocytic anemia was documented after 469 days of restriction in the self-experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a1d1133-ab9b-5643-b83f-833699c95615","slug":"macrocytic-anemia","display_name":"Macrocytic anemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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replete diet plus folic acid during recovery.\n[fol-golding2014] Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops (2014). https://pubmed.ncbi.nlm.nih.gov/25332850/ DOI: 10.1186/2193-1801-3-442","model_system":"Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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