Component
Lymphocyte response to mitogens
Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
IL-2 production declined during depletion; immune indices returned to baseline after the third repletion stage.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Eight healthy older adults in sequential dietary depletion and repletion experiment.
- exposure
- Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context.
- limitations
- Recovery occurred during a sequence of increasing intakes; no universal individual requirement or treatment dose follows.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- The observed immune changes were reversible with restored intake.
- primary_references
- [b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275
- tissue_or_cell_type
- Ex-vivo human immune-cell assays
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1681–1691
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Eight healthy older adults in sequential dietary depletion and repletion experiment. · source_derived_draft · unverified_draft
### b6-depletion-il2 IL-2 production declined during depletion; immune indices returned to baseline after the third repletion stage. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The observed immune changes were reversible with restored intake. organism: Homo sapiens tissue_or_cell_type: Ex-vivo human immune-cell assays experimental_model: Eight healthy older adults in sequential dietary depletion and repletion experiment. limitations: Recovery occurred during a sequence of increasing intakes; no universal individual requirement or treatment dose follows. exposure: Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context. [b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275
Complete structured claim and evidenceDepletion reduced circulating lymphocyte number/percentage and lymphocyte responses to T- and B-cell mitogens.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Eight healthy older adults in sequential dietary depletion and repletion experiment.
- exposure
- Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context.
- limitations
- Eight-person sequential design; not evidence that supplementing adequate people prevents infection.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- Too little B6 weakened measured immune-cell responses in this experiment.
- primary_references
- [b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275
- tissue_or_cell_type
- Human circulating lymphocytes and ex-vivo cultures
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1669–1679
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Eight healthy older adults in sequential dietary depletion and repletion experiment. · source_derived_draft · unverified_draft
### b6-depletion-lymphocytes Depletion reduced circulating lymphocyte number/percentage and lymphocyte responses to T- and B-cell mitogens. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Too little B6 weakened measured immune-cell responses in this experiment. organism: Homo sapiens tissue_or_cell_type: Human circulating lymphocytes and ex-vivo cultures experimental_model: Eight healthy older adults in sequential dietary depletion and repletion experiment. limitations: Eight-person sequential design; not evidence that supplementing adequate people prevents infection. exposure: Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context. [b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.