{"id":"278e519c-5702-5185-b91e-b974af194a2f","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-depletion-il2","predicate":"depletion_reduced_il2_production","statement":"IL-2 production declined during depletion; immune indices returned to baseline after the third repletion stage.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1143c227-e3b2-58d8-b9be-a147371ff135","mechanism_event_label":"The observed immune changes were reversible with restored intake.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"94bdd5a2-efea-569c-84ff-ecca28ab1b6a","slug":"il2-protein","display_name":"IL-2","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"1143c227-e3b2-58d8-b9be-a147371ff135","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-depletion-il2-event","event_type":"observed_intervention","label":"The observed immune changes were reversible with restored intake.","description":"IL-2 production declined during depletion; immune indices returned to baseline after the third repletion stage.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c21f4634-113f-59cb-8378-9120b1ad4312","slug":"lymphocyte-mitogen-response","display_name":"Lymphocyte response to mitogens","entity_type_key":"cellular_process"},"role":"recovery_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"94bdd5a2-efea-569c-84ff-ecca28ab1b6a","slug":"il2-protein","display_name":"IL-2","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Eight healthy older adults in sequential dietary depletion and repletion experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Recovery occurred during a sequence of increasing intakes; no universal individual requirement or treatment dose follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The observed immune changes were reversible with restored intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ex-vivo human immune-cell assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f2ab7540-e712-5450-9b4b-3cab0e939961","evidence_kind":"source_excerpt","locator":"Lines 1681-1691","start_line":1681,"end_line":1691,"excerpt":"### b6-depletion-il2\nIL-2 production declined during depletion; immune indices returned to baseline after the third repletion stage.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The observed immune changes were reversible with restored intake.\norganism: Homo sapiens\ntissue_or_cell_type: Ex-vivo human immune-cell assays\nexperimental_model: Eight healthy older adults in sequential dietary depletion and repletion experiment.\nlimitations: Recovery occurred during a sequence of increasing intakes; no universal individual requirement or treatment dose follows.\nexposure: Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context.\n[b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275","model_system":"Eight healthy older adults in sequential dietary depletion and repletion experiment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}