{"id":"12117579-a8e8-57e2-a322-f219ba8affa0","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-depletion-lymphocytes","predicate":"depletion_reduced_lymphocyte_indices","statement":"Depletion reduced circulating lymphocyte number/percentage and lymphocyte responses to T- and B-cell mitogens.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d42df894-8753-52c2-9267-87a804f1cdf2","mechanism_event_label":"Too little B6 weakened measured immune-cell responses in this experiment.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"2a53991c-d3b9-57f5-be0e-0fc6f7d6ac33","slug":"circulating-lymphocyte-count","display_name":"Circulating lymphocyte count","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d42df894-8753-52c2-9267-87a804f1cdf2","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-depletion-lymphocytes-event","event_type":"observed_intervention","label":"Too little B6 weakened measured immune-cell responses in this experiment.","description":"Depletion reduced circulating lymphocyte number/percentage and lymphocyte responses to T- and B-cell mitogens.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c21f4634-113f-59cb-8378-9120b1ad4312","slug":"lymphocyte-mitogen-response","display_name":"Lymphocyte response to mitogens","entity_type_key":"cellular_process"},"role":"functional_readout","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2a53991c-d3b9-57f5-be0e-0fc6f7d6ac33","slug":"circulating-lymphocyte-count","display_name":"Circulating lymphocyte count","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Eight healthy older adults in sequential dietary depletion and repletion experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eight-person sequential design; not evidence that supplementing adequate people prevents infection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Too little B6 weakened measured immune-cell responses in this experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating lymphocytes and ex-vivo cultures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a13c2b8a-c0c0-56ee-9e55-a2e87db1a858","evidence_kind":"source_excerpt","locator":"Lines 1669-1679","start_line":1669,"end_line":1679,"excerpt":"### b6-depletion-lymphocytes\nDepletion reduced circulating lymphocyte number/percentage and lymphocyte responses to T- and B-cell mitogens.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Too little B6 weakened measured immune-cell responses in this experiment.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating lymphocytes and ex-vivo cultures\nexperimental_model: Eight healthy older adults in sequential dietary depletion and repletion experiment.\nlimitations: Eight-person sequential design; not evidence that supplementing adequate people prevents infection.\nexposure: Depletion up to 20 days, then three 21-day repletion stages; final short 50 mg/day phase. Repletion-stage intakes are historical experimental context.\n[b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275","model_system":"Eight healthy older adults in sequential dietary depletion and repletion experiment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-meydani1991] Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults (1991). https://pubmed.ncbi.nlm.nih.gov/2021134/ DOI: 10.1093/ajcn/53.5.1275","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}