Component
LPS-induced cytokine release in human monocytes or PBMCs
LPS-induced cytokine release in human monocytes or PBMCs. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Sulforaphane suppressed LPS-induced cytokine secretion in THP-1 cells and human PBMC experiments.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/sulforaphane-research/25284333.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a293f12863f5cfc2d57d74f4acee8c62700e2744a5900643bc23eca85c62be5", "start_char": 0, "end_char": 1494, "text_sha256": "0a293f12863f5cfc2d57d74f4acee8c62700e2744a5900643bc23eca85c62be5"}
- experimental_model
- Recombinant receptor mapping, human cell exposure and ex vivo challenge
- exposure
- Sulforaphane under non-reducing conditions; LPS challenge after ITC exposure
- limitations
- Covalent mapping does not establish the sole cause of cytokine effects; not a chronic-disease outcome trial.
- nutrient_topic
- Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
- organism
- Human TLR4, THP-1 monocytes and donor PBMCs
- plain_language
- An inflammatory challenge produced a smaller response in these systems.
- primary_references
- [sulforaphane-p25284333] Suppression of LPS-induced transcription and cytokine secretion by the dietary isothiocyanate sulforaphane. (2014). https://pubmed.ncbi.nlm.nih.gov/25284333/ DOI: 10.1002/mnfr.201400550
- tissue_or_cell_type
- LPS recognition and cytokine secretion
Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 684–695
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant receptor mapping, human cell exposure and ex vivo challenge · source_derived_draft · unverified_draft
### sulforaphane-lps-response Sulforaphane suppressed LPS-induced cytokine secretion in THP-1 cells and human PBMC experiments. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: An inflammatory challenge produced a smaller response in these systems. organism: Human TLR4, THP-1 monocytes and donor PBMCs tissue_or_cell_type: LPS recognition and cytokine secretion experimental_model: Recombinant receptor mapping, human cell exposure and ex vivo challenge limitations: Covalent mapping does not establish the sole cause of cytokine effects; not a chronic-disease outcome trial. exposure: Sulforaphane under non-reducing conditions; LPS challenge after ITC exposure evidence_span: {"source_cache": "artifacts/sulforaphane-research/25284333.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a293f12863f5cfc2d57d74f4acee8c62700e2744a5900643bc23eca85c62be5", "start_char": 0, "end_char": 1494, "text_sha256": "0a293f12863f5cfc2d57d74f4acee8c62700e2744a5900643bc23eca85c62be5"} [sulforaphane-p25284333] Suppression of LPS-induced transcription and cytokine secretion by the dietary isothiocyanate sulforaphane. (2014). https://pubmed.ncbi.nlm.nih.gov/25284333/ DOI: 10.1002/mnfr.201400550
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.