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(2014). https://pubmed.ncbi.nlm.nih.gov/25284333/ DOI: 10.1002/mnfr.201400550","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"LPS recognition and cytokine secretion","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0e39503a-7bdb-5138-b42e-08c0f17cbbd4","evidence_kind":"source_excerpt","locator":"Lines 684-695","start_line":684,"end_line":695,"excerpt":"### sulforaphane-lps-response\nSulforaphane suppressed LPS-induced cytokine secretion in THP-1 cells and human PBMC experiments.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An inflammatory challenge produced a smaller response in these systems.\norganism: Human TLR4, THP-1 monocytes and donor PBMCs\ntissue_or_cell_type: LPS recognition and cytokine secretion\nexperimental_model: Recombinant receptor mapping, human cell exposure and ex vivo challenge\nlimitations: Covalent mapping does not establish the sole cause of cytokine effects; not a chronic-disease outcome trial.\nexposure: Sulforaphane under non-reducing conditions; LPS challenge after ITC exposure\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/25284333.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0a293f12863f5cfc2d57d74f4acee8c62700e2744a5900643bc23eca85c62be5\", \"start_char\": 0, \"end_char\": 1494, \"text_sha256\": \"0a293f12863f5cfc2d57d74f4acee8c62700e2744a5900643bc23eca85c62be5\"}\n[sulforaphane-p25284333] Suppression of LPS-induced transcription and cytokine secretion by the dietary isothiocyanate sulforaphane. 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