Component
Lysophosphatidylcholine 22:6
DHA-containing lysophosphatidylcholine; regiospecificity not assigned beyond the primary lipidomics evidence.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mfsd2a transported DHA carried by lysophosphatidylcholine rather than unesterified DHA in the tested system.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"}
- experimental_model
- Mouse knockout and cell transport experiments
- exposure
- LPC-bound versus unesterified DHA; sodium-dependent transport
- limitations
- LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mouse Mfsd2a and experimental expression system
- plain_language
- The chemical package used to carry DHA mattered.
- primary_references
- [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
- tissue_or_cell_type
- Blood-brain-barrier endothelium
- transport_effect
- raises Mfsd2a is recorded as the influx route carrying DHA as lysophosphatidylcholine.
- transport_pool
- the brain-endothelial cell interior Mfsd2a is recorded as the influx route carrying DHA as lysophosphatidylcholine.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 945–956
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse knockout and cell transport experiments · source_derived_draft · unverified_draft
### choline-mfsd2a-lpc Mfsd2a transported DHA carried by lysophosphatidylcholine rather than unesterified DHA in the tested system. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The chemical package used to carry DHA mattered. organism: Mouse Mfsd2a and experimental expression system tissue_or_cell_type: Blood-brain-barrier endothelium experimental_model: Mouse knockout and cell transport experiments limitations: LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA. exposure: LPC-bound versus unesterified DHA; sodium-dependent transport evidence_span: {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"} [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
Complete structured claim and evidence
Where it participates (unsigned role)
Mfsd2a-mediated LPC transport was sodium-dependent.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"}
- experimental_model
- Mouse knockout and cell transport experiments
- exposure
- LPC-bound versus unesterified DHA; sodium-dependent transport
- limitations
- LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mouse Mfsd2a and experimental expression system
- plain_language
- This lipid transport route also depends on an ion gradient.
- primary_references
- [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
- tissue_or_cell_type
- Blood-brain-barrier endothelium
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 958–969
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse knockout and cell transport experiments · source_derived_draft · unverified_draft
### choline-mfsd2a-sodium Mfsd2a-mediated LPC transport was sodium-dependent. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: This lipid transport route also depends on an ion gradient. organism: Mouse Mfsd2a and experimental expression system tissue_or_cell_type: Blood-brain-barrier endothelium experimental_model: Mouse knockout and cell transport experiments limitations: LPC-DHA is a choline-containing lipid, not free choline. No claim that oral choline necessarily raises brain DHA. exposure: LPC-bound versus unesterified DHA; sodium-dependent transport evidence_span: {"source_cache": "artifacts/choline-research/24828044.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695", "start_char": 0, "end_char": 1689, "text_sha256": "3ec710edae591ed103960d73b49918a61b0260b22702926792e7133337b93695"} [choline-p24828044] Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. (2014). https://pubmed.ncbi.nlm.nih.gov/24828044/ DOI: 10.1038/nature13241
Complete structured claim and evidenceEmbryos from vitamin E-depleted zebrafish parents incorporated more water-18O label into LPC 22:6 and three DHA-containing phosphatidylcholines during 48–72 hours post-fertilization than vitamin E-sufficient controls, supporting increased acyl turnover.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- true
- evidence_location
- Figure 7; isotope-labeling Methods
- experimental_model
- Parental diet manipulation and stable-isotope lipidomics
- exposure
- Parents fed no added E or 500 mg RRR-alpha-tocopheryl acetate/kg for ≥80 days; embryos incubated in 40% H2(18)O from 48 to 72 hpf.
- limitations
- Embryos rely on maternally deposited nutrients; whole-embryo tracing does not directly measure brain delivery or prove a particular repair enzyme.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Danio rerio
- plain_language
- Labeled-water tracing showed faster turnover of selected DHA lipids during vitamin E depletion.
- primary_references
- [ver-mcdougall2016] Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos. (2016). https://pubmed.ncbi.nlm.nih.gov/26774753/ DOI: 10.1016/j.redox.2016.01.004
- tissue_or_cell_type
- Whole embryos
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 760–772
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Parental diet manipulation and stable-isotope lipidomics · source_derived_draft · unverified_draft
### ver-dha-remodeling-flux Embryos from vitamin E-depleted zebrafish parents incorporated more water-18O label into LPC 22:6 and three DHA-containing phosphatidylcholines during 48–72 hours post-fertilization than vitamin E-sufficient controls, supporting increased acyl turnover. Condition category: nutrient_deficiency nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Labeled-water tracing showed faster turnover of selected DHA lipids during vitamin E depletion. organism: Danio rerio tissue_or_cell_type: Whole embryos experimental_model: Parental diet manipulation and stable-isotope lipidomics limitations: Embryos rely on maternally deposited nutrients; whole-embryo tracing does not directly measure brain delivery or prove a particular repair enzyme. exposure: Parents fed no added E or 500 mg RRR-alpha-tocopheryl acetate/kg for ≥80 days; embryos incubated in 40% H2(18)O from 48 to 72 hpf. cross_nutrient: true evidence_location: Figure 7; isotope-labeling Methods [ver-mcdougall2016] Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos. (2016). https://pubmed.ncbi.nlm.nih.gov/26774753/ DOI: 10.1016/j.redox.2016.01.004
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.