Component
Human lamin A/C / LMNA
Human lamin A/C / LMNA. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lamin A/C upregulation was confirmed by immunoblotting.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/36076497.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "70d2217b479c3b8e299fd8b94dda90a12086be9c8ed756ad3359dc4272285a0a", "start_char": 0, "end_char": 1645, "text_sha256": "70d2217b479c3b8e299fd8b94dda90a12086be9c8ed756ad3359dc4272285a0a"}
- experimental_model
- Quantitative proteomics, immunoblots and endothelial functional assays
- exposure
- 5 micromolar CGA for 24 hours
- limitations
- An immortalized cell model, not intact human vessels. Enrichment of PI3K/AKT and Rap1 pathways is hypothesis generation; increased angiogenesis is not universally desirable.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Human EA.hy926 cell line
- plain_language
- A nuclear structural protein also changed.
- primary_references
- [chlorogenic_acid-p36076497] Chlorogenic acid enhances endothelial barrier function and promotes endothelial tube formation: A proteomics approach and functional validation. (2022). https://pubmed.ncbi.nlm.nih.gov/36076497/ DOI: 10.1016/j.biopha.2022.113471
- tissue_or_cell_type
- Cultured endothelial-like cells
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 633–644
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Quantitative proteomics, immunoblots and endothelial functional assays · source_derived_draft · unverified_draft
### chlorogenic_acid-lmna Lamin A/C upregulation was confirmed by immunoblotting. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A nuclear structural protein also changed. organism: Human EA.hy926 cell line tissue_or_cell_type: Cultured endothelial-like cells experimental_model: Quantitative proteomics, immunoblots and endothelial functional assays limitations: An immortalized cell model, not intact human vessels. Enrichment of PI3K/AKT and Rap1 pathways is hypothesis generation; increased angiogenesis is not universally desirable. exposure: 5 micromolar CGA for 24 hours evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/36076497.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "70d2217b479c3b8e299fd8b94dda90a12086be9c8ed756ad3359dc4272285a0a", "start_char": 0, "end_char": 1645, "text_sha256": "70d2217b479c3b8e299fd8b94dda90a12086be9c8ed756ad3359dc4272285a0a"} [chlorogenic_acid-p36076497] Chlorogenic acid enhances endothelial barrier function and promotes endothelial tube formation: A proteomics approach and functional validation. (2022). https://pubmed.ncbi.nlm.nih.gov/36076497/ DOI: 10.1016/j.biopha.2022.113471
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.