Component
Liver stiffness measured by elastography
Liver stiffness measured by elastography. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
CGA did not outperform placebo for liver stiffness.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/33838673.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "749cbe05e73aeb9c4a69c8c00e8a3839241f343b5c0eb9662b64f4127506f319", "start_char": 0, "end_char": 2205, "text_sha256": "749cbe05e73aeb9c4a69c8c00e8a3839241f343b5c0eb9662b64f4127506f319"}
- experimental_model
- Six-month double-blind randomized four-arm trial
- exposure
- Daily 200 mg CGA, 200 mg caffeine, both, or starch placebo
- limitations
- Chronic human liver disease differs from surgical mouse regeneration. The trial does not isolate all possible formulations, but its null hepatic result must remain visible.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Human participants with type 2 diabetes and NAFLD
- plain_language
- A separate fibrosis-related measurement was also null.
- primary_references
- [chlorogenic_acid-p33838673] Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33838673/ DOI: 10.1186/s12937-021-00694-5
- tissue_or_cell_type
- FibroScan, hepatic blood tests, metabolic and inflammatory markers
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 1049–1060
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-month double-blind randomized four-arm trial · source_derived_draft · unverified_draft
### chlorogenic_acid-liver-stiffness-null CGA did not outperform placebo for liver stiffness. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A separate fibrosis-related measurement was also null. organism: Human participants with type 2 diabetes and NAFLD tissue_or_cell_type: FibroScan, hepatic blood tests, metabolic and inflammatory markers experimental_model: Six-month double-blind randomized four-arm trial limitations: Chronic human liver disease differs from surgical mouse regeneration. The trial does not isolate all possible formulations, but its null hepatic result must remain visible. exposure: Daily 200 mg CGA, 200 mg caffeine, both, or starch placebo evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/33838673.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "749cbe05e73aeb9c4a69c8c00e8a3839241f343b5c0eb9662b64f4127506f319", "start_char": 0, "end_char": 2205, "text_sha256": "749cbe05e73aeb9c4a69c8c00e8a3839241f343b5c0eb9662b64f4127506f319"} [chlorogenic_acid-p33838673] Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33838673/ DOI: 10.1186/s12937-021-00694-5
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.