Component
Alcohol-associated liver cancer
Alcohol-associated liver cancer. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
ALDH2 deficiency promoted alcohol-associated liver cancer by activating oncogenic pathways via oxidised-DNA-enriched extracellular vesicles.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/31279903.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a0e9d2f127fd9454b41431aa6ed4bdcfd30723cc3acee2a1678015ac5299887", "start_char": 0, "end_char": 2706, "text_sha256": "3a0e9d2f127fd9454b41431aa6ed4bdcfd30723cc3acee2a1678015ac5299887"}
- experimental_model
- ALDH2-deficient mice and human samples with extracellular vesicle analysis
- exposure
- Alcohol exposure on an ALDH2-deficient background
- limitations
- Proposes a specific transmissible mechanism. The oncogenic pathway activation is measured in a model, not in treated patients.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Mouse and human samples
- plain_language
- Damaged DNA is packaged into vesicles that carry the cancer signal to other cells.
- primary_references
- [alcohol-p31279903] ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. (2019). https://pubmed.ncbi.nlm.nih.gov/31279903/ DOI: 10.1016/j.jhep.2019.06.018
- tissue_or_cell_type
- Liver
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 553–564
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ALDH2-deficient mice and human samples with extracellular vesicle analysis · source_derived_draft · unverified_draft
### alcohol-aldh2-liver-cancer ALDH2 deficiency promoted alcohol-associated liver cancer by activating oncogenic pathways via oxidised-DNA-enriched extracellular vesicles. Condition category: machinery_impairment nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Damaged DNA is packaged into vesicles that carry the cancer signal to other cells. organism: Mouse and human samples tissue_or_cell_type: Liver experimental_model: ALDH2-deficient mice and human samples with extracellular vesicle analysis limitations: Proposes a specific transmissible mechanism. The oncogenic pathway activation is measured in a model, not in treated patients. exposure: Alcohol exposure on an ALDH2-deficient background evidence_span: {"source_cache": "artifacts/alcohol-research/31279903.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a0e9d2f127fd9454b41431aa6ed4bdcfd30723cc3acee2a1678015ac5299887", "start_char": 0, "end_char": 2706, "text_sha256": "3a0e9d2f127fd9454b41431aa6ed4bdcfd30723cc3acee2a1678015ac5299887"} [alcohol-p31279903] ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. (2019). https://pubmed.ncbi.nlm.nih.gov/31279903/ DOI: 10.1016/j.jhep.2019.06.018
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.