Component
Lipophilic statins studied in the UBIAD1 assay
Lipophilic statins studied in the UBIAD1 assay. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The tested lipophilic statins inhibited UBIAD1 enzymatic activity in microsomal assays.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/25874989.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a3eb5f4c56ca7a3e70a32c020bba09f4fec5e91048b13a188017bf221f713a68", "start_char": 0, "end_char": 1777, "text_sha256": "a3eb5f4c56ca7a3e70a32c020bba09f4fec5e91048b13a188017bf221f713a68"}
- experimental_model
- Microsomal prenylation assays
- exposure
- Lipophilic statin exposure
- limitations
- Direct in-vitro inhibition; neither a clinical statin-to-K2-deficiency cascade nor a K2 supplementation indication is established.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Human UBIAD1 expressed in insect cells
- plain_language
- A drug-enzyme interaction is searchable without assuming it causes deficiency at usual treatment exposure.
- primary_references
- [k2-p25874989] Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. (2015). https://pubmed.ncbi.nlm.nih.gov/25874989/ DOI: 10.1371/journal.pone.0125737
- tissue_or_cell_type
- MK-4 synthesis
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 851–862
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microsomal prenylation assays · source_derived_draft · unverified_draft
### k2-ubiad-statin-context The tested lipophilic statins inhibited UBIAD1 enzymatic activity in microsomal assays. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A drug-enzyme interaction is searchable without assuming it causes deficiency at usual treatment exposure. organism: Human UBIAD1 expressed in insect cells tissue_or_cell_type: MK-4 synthesis experimental_model: Microsomal prenylation assays limitations: Direct in-vitro inhibition; neither a clinical statin-to-K2-deficiency cascade nor a K2 supplementation indication is established. exposure: Lipophilic statin exposure evidence_span: {"source_cache": "artifacts/k2-research/25874989.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a3eb5f4c56ca7a3e70a32c020bba09f4fec5e91048b13a188017bf221f713a68", "start_char": 0, "end_char": 1777, "text_sha256": "a3eb5f4c56ca7a3e70a32c020bba09f4fec5e91048b13a188017bf221f713a68"} [k2-p25874989] Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. (2015). https://pubmed.ncbi.nlm.nih.gov/25874989/ DOI: 10.1371/journal.pone.0125737
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.