{"id":"aa8aa38a-51d0-5729-843f-a5d277c2cc3f","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-ubiad-statin-context","predicate":"activity_inhibited_by_tested_exposure","statement":"The tested lipophilic statins inhibited UBIAD1 enzymatic activity in microsomal assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a44439c6-37ee-5cec-911b-bed6b8a17a59","mechanism_event_label":"A drug-enzyme interaction is searchable without assuming it causes deficiency at usual treatment exposure.","subject":{"id":"190c8a9f-60f4-5341-898e-187a0c697624","slug":"ubiad1","display_name":"Human UBIAD1 prenyltransferase","entity_type_key":"protein"},"object":{"id":"45a5bc37-2612-5dc6-9319-3a7b7f9857b2","slug":"lipophilic-statins","display_name":"Lipophilic statins studied in the UBIAD1 assay","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"a44439c6-37ee-5cec-911b-bed6b8a17a59","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-ubiad-statin-context-event","event_type":"biochemical_relationship","label":"A drug-enzyme interaction is searchable without assuming it causes deficiency at usual treatment exposure.","description":"The tested lipophilic statins inhibited UBIAD1 enzymatic activity in microsomal assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"190c8a9f-60f4-5341-898e-187a0c697624","slug":"ubiad1","display_name":"Human UBIAD1 prenyltransferase","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"45a5bc37-2612-5dc6-9319-3a7b7f9857b2","slug":"lipophilic-statins","display_name":"Lipophilic statins studied in the UBIAD1 assay","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/25874989.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a3eb5f4c56ca7a3e70a32c020bba09f4fec5e91048b13a188017bf221f713a68\", \"start_char\": 0, \"end_char\": 1777, \"text_sha256\": \"a3eb5f4c56ca7a3e70a32c020bba09f4fec5e91048b13a188017bf221f713a68\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Microsomal prenylation assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lipophilic statin exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Direct in-vitro inhibition; neither a clinical statin-to-K2-deficiency cascade nor a K2 supplementation indication is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human UBIAD1 expressed in insect cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A drug-enzyme interaction is searchable without assuming it causes deficiency at usual treatment exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p25874989] Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. 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