Component

Human hepatic lipase / LIPC

Human hepatic lipase / LIPC. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Hepatic lipase increased carotenoid uptake in HDL-treated SR-BI-expressing cells, favoring lutein/zeaxanthin over beta-carotene.

    Human hepatic lipase / LIPC → Lutein uptake by engineered human HEK293 cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lutein-research/36863431.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "530dd42d442890be2e5cd11c18bf95c0bd850d8f67ad6682d12360dfc7f8aec0", "start_char": 0, "end_char": 1551, "text_sha256": "530dd42d442890be2e5cd11c18bf95c0bd850d8f67ad6682d12360dfc7f8aec0"}
    experimental_model
    SR-BI expression, tunnel mutation, binding and lipoprotein-partner assays
    exposure
    Wild-type or C384Y SR-BI; HDL and hepatic lipase additions
    limitations
    Engineered-cell mechanisms, not a clinical HDL-raising recommendation; no selective direct binding to lutein demonstrated.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Human HEK293 cell system
    plain_language
    A lipoprotein-processing partner changed pigment delivery.
    primary_references
    [lutein-p36863431] Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI. (2023). https://pubmed.ncbi.nlm.nih.gov/36863431/ DOI: 10.1016/j.exer.2023.109429
    tissue_or_cell_type
    Engineered cells without endogenous SR-BI

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 684–695

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SR-BI expression, tunnel mutation, binding and lipoprotein-partner assays · source_derived_draft · unverified_draft

    ### lutein-lipc-cell-uptake Hepatic lipase increased carotenoid uptake in HDL-treated SR-BI-expressing cells, favoring lutein/zeaxanthin over beta-carotene. Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: A lipoprotein-processing partner changed pigment delivery. organism: Human HEK293 cell system tissue_or_cell_type: Engineered cells without endogenous SR-BI experimental_model: SR-BI expression, tunnel mutation, binding and lipoprotein-partner assays limitations: Engineered-cell mechanisms, not a clinical HDL-raising recommendation; no selective direct binding to lutein demonstrated. exposure: Wild-type or C384Y SR-BI; HDL and hepatic lipase additions evidence_span: {"source_cache": "artifacts/lutein-research/36863431.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "530dd42d442890be2e5cd11c18bf95c0bd850d8f67ad6682d12360dfc7f8aec0", "start_char": 0, "end_char": 1551, "text_sha256": "530dd42d442890be2e5cd11c18bf95c0bd850d8f67ad6682d12360dfc7f8aec0"} [lutein-p36863431] Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI. (2023). https://pubmed.ncbi.nlm.nih.gov/36863431/ DOI: 10.1016/j.exer.2023.109429
    Complete structured claim and evidence

  2. LIPC accumulated specifically in the subfoveal RPE.

    Human hepatic lipase / LIPC → Human subfoveal RPE protein enrichment source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/zeaxanthin-research/39151780.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4", "start_char": 0, "end_char": 1282, "text_sha256": "e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4"}
    experimental_model
    Confocal Raman/fluorescence imaging and expression analysis
    exposure
    Twelve carotenoid-related proteins; Western blot and single-cell RNA database
    limitations
    Localization is not proof of transport direction or rate. Regional BCO2 result differs from the 2025 study; antibody specificity, sampling and compartment remain unresolved comparison variables.
    nutrient_topic
    Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. · Dietary (3R,3-prime-R)-zeaxanthin
    organism
    Human donor retina and RPE
    plain_language
    A partner of SR-BI showed a local distribution.
    primary_references
    [zeaxanthin-p39151780] Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy. (2024). https://pubmed.ncbi.nlm.nih.gov/39151780/ DOI: 10.1016/j.exer.2024.110043
    tissue_or_cell_type
    Central versus peripheral retinal regions

    Zeaxanthin: metabolism, signaling and nutrient connections (2026-09-17) · lines 574–585

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Confocal Raman/fluorescence imaging and expression analysis · source_derived_draft · unverified_draft

    ### zeaxanthin-lipc-subfoveal LIPC accumulated specifically in the subfoveal RPE. Condition category: normal nutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A partner of SR-BI showed a local distribution. organism: Human donor retina and RPE tissue_or_cell_type: Central versus peripheral retinal regions experimental_model: Confocal Raman/fluorescence imaging and expression analysis limitations: Localization is not proof of transport direction or rate. Regional BCO2 result differs from the 2025 study; antibody specificity, sampling and compartment remain unresolved comparison variables. exposure: Twelve carotenoid-related proteins; Western blot and single-cell RNA database evidence_span: {"source_cache": "artifacts/zeaxanthin-research/39151780.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4", "start_char": 0, "end_char": 1282, "text_sha256": "e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4"} [zeaxanthin-p39151780] Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy. (2024). https://pubmed.ncbi.nlm.nih.gov/39151780/ DOI: 10.1016/j.exer.2024.110043
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards