{"id":"1c71e56f-dca9-5133-8769-527dcc62465e","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-lipc-subfoveal","predicate":"enriched_in","statement":"LIPC accumulated specifically in the subfoveal RPE.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"34d7c985-0a09-5e9f-926f-f8a3698d1605","mechanism_event_label":"A partner of SR-BI showed a local distribution.","subject":{"id":"95e61872-d850-5850-8d36-b062317dcd55","slug":"lipc","display_name":"Human hepatic lipase / LIPC","entity_type_key":"protein"},"object":{"id":"0ccbabd4-8856-54ac-91f0-5ccae4010fa8","slug":"human-subfoveal-rpe-protein-abundance","display_name":"Human subfoveal RPE protein enrichment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"34d7c985-0a09-5e9f-926f-f8a3698d1605","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-lipc-subfoveal-event","event_type":"biochemical_relationship","label":"A partner of SR-BI showed a local distribution.","description":"LIPC accumulated specifically in the subfoveal RPE.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"95e61872-d850-5850-8d36-b062317dcd55","slug":"lipc","display_name":"Human hepatic lipase / LIPC","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0ccbabd4-8856-54ac-91f0-5ccae4010fa8","slug":"human-subfoveal-rpe-protein-abundance","display_name":"Human subfoveal RPE protein enrichment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zeaxanthin-research/39151780.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4\", \"start_char\": 0, \"end_char\": 1282, \"text_sha256\": \"e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Confocal Raman/fluorescence imaging and expression analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Twelve carotenoid-related proteins; Western blot and single-cell RNA database","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Localization is not proof of transport direction or rate. Regional BCO2 result differs from the 2025 study; antibody specificity, sampling and compartment remain unresolved comparison variables.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human donor retina and RPE","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A partner of SR-BI showed a local distribution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zeaxanthin-p39151780] Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy. (2024). https://pubmed.ncbi.nlm.nih.gov/39151780/ DOI: 10.1016/j.exer.2024.110043","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Central versus peripheral retinal regions","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4d5a291d-358a-5a49-b0cf-b0df33ceeef5","evidence_kind":"source_excerpt","locator":"Lines 574-585","start_line":574,"end_line":585,"excerpt":"### zeaxanthin-lipc-subfoveal\nLIPC accumulated specifically in the subfoveal RPE.\nCondition category: normal\nnutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A partner of SR-BI showed a local distribution.\norganism: Human donor retina and RPE\ntissue_or_cell_type: Central versus peripheral retinal regions\nexperimental_model: Confocal Raman/fluorescence imaging and expression analysis\nlimitations: Localization is not proof of transport direction or rate. Regional BCO2 result differs from the 2025 study; antibody specificity, sampling and compartment remain unresolved comparison variables.\nexposure: Twelve carotenoid-related proteins; Western blot and single-cell RNA database\nevidence_span: {\"source_cache\": \"artifacts/zeaxanthin-research/39151780.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4\", \"start_char\": 0, \"end_char\": 1282, \"text_sha256\": \"e43805b4445f15c3f6490ab163d908ee7a43f475538b3160fc1ea9771cff9ab4\"}\n[zeaxanthin-p39151780] Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy. 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