Component
Larval locomotor hyperactivity
Independent cellular process record; interpretation is limited by each linked claim and its study context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Exposure to 10 mM 2-OPP increased zebrafish larval hyperactivity.
Experimental context and source evidence
- experimental_model
- Wild-type Tüpfel long fin zebrafish F4 larvae exposed to 10 mM 2-OPP.
- limitations
- Classic convulsions were absent; this does not prove human seizure causation. This exposure arm did not have ALDH7A1 impairment; it is not a genetic-deficiency experiment.
- organism
- Danio rerio
- plain_language
- A disease-associated metabolite affected an animal behavior assay.
- primary_references
- [engelke2021] Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy (2021). https://www.jci.org/articles/view/148272 DOI: 10.1172/JCI148272
- tissue_or_cell_type
- Whole larvae
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 314–322
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Wild-type Tüpfel long fin zebrafish F4 larvae exposed to 10 mM 2-OPP. · source_derived_draft · unverified_draft
### 2opp-larval-hyperactivity Exposure to 10 mM 2-OPP increased zebrafish larval hyperactivity. Plain language: A disease-associated metabolite affected an animal behavior assay. Condition category: normal organism: Danio rerio tissue_or_cell_type: Whole larvae experimental_model: Wild-type Tüpfel long fin zebrafish F4 larvae exposed to 10 mM 2-OPP. limitations: Classic convulsions were absent; this does not prove human seizure causation. This exposure arm did not have ALDH7A1 impairment; it is not a genetic-deficiency experiment. [engelke2021] Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy (2021). https://www.jci.org/articles/view/148272 DOI: 10.1172/JCI148272
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.