Component
Lactase-phlorizin hydrolase / LCT
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In rat jejunum/ileum perfusion, phlorizin hydrolysis to aglycone preceded intestinal conjugation and transport, and only conjugated forms entered mesenteric blood.
Experimental context and source evidence
- dose
- Phlorizin or phloretin 15 nmol/min for 30 minutes
- duration
- 30 minutes
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- In-situ rat jejunum plus ileum perfusion
- limitations
- Rat intestinal handling may not quantify human exposure; conjugate identities and free fractions determine downstream action.
- nutrient_topic
- Phlorizin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Phlorizin
- organism
- In-situ rat jejunum plus ileum perfusion
- plain_language
- In rat jejunum/ileum perfusion, phlorizin hydrolysis to aglycone preceded intestinal conjugation and transport, and only conjugated forms entered mesenteric blood.
- primary_references
- Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11481403/ DOI: 10.1093/jn/131.8.2109
- route
- Intestinal perfusion
- tissue
- Luminal, mucosal and mesenteric-blood metabolites
Phlorizin: mechanism of action and interactions (2026-09-20) · lines 44–53
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · In-situ rat jejunum plus ileum perfusion · source_derived_draft · unverified_draft
## phlorizin-intestinal-hydrolysis In rat jejunum/ileum perfusion, phlorizin hydrolysis to aglycone preceded intestinal conjugation and transport, and only conjugated forms entered mesenteric blood. Model/species: In-situ rat jejunum plus ileum perfusion Tissue/system: Luminal, mucosal and mesenteric-blood metabolites Exposure: Phlorizin or phloretin 15 nmol/min for 30 minutes Route: Intestinal perfusion Duration: 30 minutes Limits: Rat intestinal handling may not quantify human exposure; conjugate identities and free fractions determine downstream action. Primary reference: Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats. (2001). https://pubmed.ncbi.nlm.nih.gov/11481403/ DOI: 10.1093/jn/131.8.2109 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.