Component
Recovery of infused carbon label as expired carbon dioxide
Recovery of infused carbon label as expired carbon dioxide. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
In postabsorptive volunteers 81.2% of infused label was recovered as labelled carbon dioxide from carbon-1 labelled acetate against 53.1% from carbon-2 labelled acetate, and in dogs recovery was 75.9% against 40.8%, leading to the conclusion that the position of the label in acetyl-CoA determines the extent to which oxidation of labelled acetyl-CoA is reflected in labelled carbon dioxide excretion.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/acetate-research/2106256.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fc8e7ceab96e74e4664a17fce6b32ff0b498204a2c2c0df7437a4f6bfe1c5105", "start_char": 0, "end_char": 1005, "text_sha256": "fc8e7ceab96e74e4664a17fce6b32ff0b498204a2c2c0df7437a4f6bfe1c5105"}
- experimental_model
- Carbon-labelled acetate infusion in four to six human volunteers and in anaesthetised dogs
- exposure
- Infusion of acetate labelled at carbon 1 or carbon 2, with recovery measured as labelled carbon dioxide
- limitations
- A methodological result. It applies to every tracer study of substrate oxidation in this collection and elsewhere, and it means such studies underestimate oxidation unless corrected.
- nutrient_topic
- Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. · Acetic acid
- organism
- Human and dog
- plain_language
- Where the label sits on the molecule changes how much comes back out as carbon dioxide, so tracer studies of acetate need correcting.
- primary_references
- [acetate-p2106256] Recovery of labeled CO2 during the infusion of C-1- vs C-2-labeled acetate: implications for tracer studies of substrate oxidation. (1990). https://pubmed.ncbi.nlm.nih.gov/2106256/ DOI: 10.1093/ajcn/51.2.248
- tissue_or_cell_type
- Whole body
Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21) · lines 511–522
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Carbon-labelled acetate infusion in four to six human volunteers and in anaesthetised dogs · source_derived_draft · unverified_draft
### acetate-label-position-matters In postabsorptive volunteers 81.2% of infused label was recovered as labelled carbon dioxide from carbon-1 labelled acetate against 53.1% from carbon-2 labelled acetate, and in dogs recovery was 75.9% against 40.8%, leading to the conclusion that the position of the label in acetyl-CoA determines the extent to which oxidation of labelled acetyl-CoA is reflected in labelled carbon dioxide excretion. Condition category: normal nutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. plain_language: Where the label sits on the molecule changes how much comes back out as carbon dioxide, so tracer studies of acetate need correcting. organism: Human and dog tissue_or_cell_type: Whole body experimental_model: Carbon-labelled acetate infusion in four to six human volunteers and in anaesthetised dogs limitations: A methodological result. It applies to every tracer study of substrate oxidation in this collection and elsewhere, and it means such studies underestimate oxidation unless corrected. exposure: Infusion of acetate labelled at carbon 1 or carbon 2, with recovery measured as labelled carbon dioxide evidence_span: {"source_cache": "artifacts/acetate-research/2106256.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fc8e7ceab96e74e4664a17fce6b32ff0b498204a2c2c0df7437a4f6bfe1c5105", "start_char": 0, "end_char": 1005, "text_sha256": "fc8e7ceab96e74e4664a17fce6b32ff0b498204a2c2c0df7437a4f6bfe1c5105"} [acetate-p2106256] Recovery of labeled CO2 during the infusion of C-1- vs C-2-labeled acetate: implications for tracer studies of substrate oxidation. (1990). https://pubmed.ncbi.nlm.nih.gov/2106256/ DOI: 10.1093/ajcn/51.2.248
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.