Component
IP3 receptor palmitoylation
IP3 receptor palmitoylation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Low-selenium culture conditions were associated with defective IP3R palmitoylation and reduced receptor expression in the SELENOK study.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/inositol-research/25368151.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84452ee9a1f04bf54aba8030e5384d46a1dafdbb460281fd99c244e57d6644d9", "start_char": 0, "end_char": 1873, "text_sha256": "84452ee9a1f04bf54aba8030e5384d46a1dafdbb460281fd99c244e57d6644d9"}
- experimental_model
- Immune-cell perturbation, co-immunoprecipitation and palmitoylation assays
- exposure
- Selk deletion, low-selenium media, DHHC6 knockdown and IP3R cysteine mutants
- limitations
- Selenium limitation and genetic deletion are distinct. This does not establish that inositol supplements repair selenium-dependent receptor failure.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Mouse immune cells and mammalian cell models
- plain_language
- The cell may still make the message but lose a properly maintained receptor.
- primary_references
- [ino-p25368151] Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (2014). https://pubmed.ncbi.nlm.nih.gov/25368151/ DOI: 10.1073/pnas.1417176111
- tissue_or_cell_type
- ER-associated IP3 receptor machinery
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1068–1079
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Immune-cell perturbation, co-immunoprecipitation and palmitoylation assays · source_derived_draft · unverified_draft
### ino-selenium-receptor Low-selenium culture conditions were associated with defective IP3R palmitoylation and reduced receptor expression in the SELENOK study. Condition category: nutrient_deficiency nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cell may still make the message but lose a properly maintained receptor. organism: Mouse immune cells and mammalian cell models tissue_or_cell_type: ER-associated IP3 receptor machinery experimental_model: Immune-cell perturbation, co-immunoprecipitation and palmitoylation assays limitations: Selenium limitation and genetic deletion are distinct. This does not establish that inositol supplements repair selenium-dependent receptor failure. exposure: Selk deletion, low-selenium media, DHHC6 knockdown and IP3R cysteine mutants evidence_span: {"source_cache": "artifacts/inositol-research/25368151.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84452ee9a1f04bf54aba8030e5384d46a1dafdbb460281fd99c244e57d6644d9", "start_char": 0, "end_char": 1873, "text_sha256": "84452ee9a1f04bf54aba8030e5384d46a1dafdbb460281fd99c244e57d6644d9"} [ino-p25368151] Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (2014). https://pubmed.ncbi.nlm.nih.gov/25368151/ DOI: 10.1073/pnas.1417176111
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.