Component
IP3-gated intracellular calcium-channel current
Study-scoped entity; inspect species, exposure, model and limitations on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Increasing IP3 overcame inhibition, but caffeine did not reduce specific IP3 binding to the receptor.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Same canine channel preparation.
- limitations
- No human brain outcome or dietary inositol rescue was demonstrated.
- nutrient_topic
- Caffeine collection; salts, coffee, species and coexposure contexts retain their identities. · Caffeine
- plain_language
- The functional block did not simply displace the measured ligand binding.
- primary_references
- Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8186468/ · DOI 10.1091/mbc.5.1.97
Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18) · lines 396–402
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same canine channel preparation. · source_derived_draft · unverified_draft
## caf-ip3-rescue The functional block did not simply displace the measured ligand binding. Increasing IP3 overcame inhibition, but caffeine did not reduce specific IP3 binding to the receptor. Model: Same canine channel preparation. Limitations: No human brain outcome or dietary inositol rescue was demonstrated. Evidence access: Primary abstract Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8186468/ · DOI 10.1091/mbc.5.1.97
Complete structured claim and evidence
Where it participates (unsigned role)
Caffeine inhibited IP3-gated channels with half-inhibition at 1.64 mM; 5 mM reduced opening frequency more than threefold without changing conductance.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Canine cerebellar channels in planar lipid bilayers.
- limitations
- Millimolar concentrations; opposite channel effects are distinct targets, not a scientific contradiction.
- nutrient_topic
- Caffeine collection; salts, coffee, species and coexposure contexts retain their identities. · Caffeine
- plain_language
- Caffeine can inhibit one calcium-release channel while activating another.
- primary_references
- Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8186468/ · DOI 10.1091/mbc.5.1.97
Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18) · lines 388–394
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Canine cerebellar channels in planar lipid bilayers. · source_derived_draft · unverified_draft
## caf-ip3 Caffeine can inhibit one calcium-release channel while activating another. Caffeine inhibited IP3-gated channels with half-inhibition at 1.64 mM; 5 mM reduced opening frequency more than threefold without changing conductance. Model: Canine cerebellar channels in planar lipid bilayers. Limitations: Millimolar concentrations; opposite channel effects are distinct targets, not a scientific contradiction. Evidence access: Primary abstract Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8186468/ · DOI 10.1091/mbc.5.1.97
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.