Component
Intestinal pyridoxal translocation
Intestinal pyridoxal translocation
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
During apical PL incubation, basolateral PL appearance approximately matched apical disappearance, without detectable medium PLP or PMP.
Experimental context and source evidence
- evidence_location
- Results: Incubation with pyridoxal; Table 1
- experimental_model
- Polarized human Caco-2 monolayers; human intestinal lysates.
- exposure
- 100 or 1000 nM PL; 6-48 h.
- limitations
- Cell monolayer model; PL and PN transport mechanisms need not be identical.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- Pyridoxal crossed the cell layer largely as pyridoxal.
- primary_references
- [albersen2013] The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. (2013). https://pubmed.ncbi.nlm.nih.gov/23342087/ DOI: 10.1371/journal.pone.0054113
- tissue_or_cell_type
- Polarized Caco-2 monolayers
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 150–161
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Polarized human Caco-2 monolayers; human intestinal lysates. · source_derived_draft · unverified_draft
### b6-transport-enterocyte-pl-translocation During apical PL incubation, basolateral PL appearance approximately matched apical disappearance, without detectable medium PLP or PMP. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Pyridoxal crossed the cell layer largely as pyridoxal. organism: Homo sapiens tissue_or_cell_type: Polarized Caco-2 monolayers experimental_model: Polarized human Caco-2 monolayers; human intestinal lysates. limitations: Cell monolayer model; PL and PN transport mechanisms need not be identical. exposure: 100 or 1000 nM PL; 6-48 h. evidence_location: Results: Incubation with pyridoxal; Table 1 [albersen2013] The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. (2013). https://pubmed.ncbi.nlm.nih.gov/23342087/ DOI: 10.1371/journal.pone.0054113
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.