Component
Intestinal monocarboxylate-sensitive-lipoate transport
Intestinal monocarboxylate-sensitive-lipoate transport. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Caco-2 lipoic-acid transport was energy dependent, increased at acidic pH and was inhibited by tested monocarboxylates.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/17536819.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d777a0163a5cb3c8de0edf282cca050a720098f5ee7b0f4e22f9a0b3275c5b7c", "start_char": 0, "end_char": 863, "text_sha256": "d777a0163a5cb3c8de0edf282cca050a720098f5ee7b0f4e22f9a0b3275c5b7c"}
- experimental_model
- Caco-2 intestinal transport model
- exposure
- Lipoic acid transport across pH and competing-monocarboxylate conditions
- limitations
- Cell model suggests proton-linked monocarboxylate transport but does not identify a specific SLC16 isoform or quantify whole-person absorption.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Human cell line
- plain_language
- Absorption behavior depended on acidity and competing molecules in this cell model.
- primary_references
- [ala-p17536819] Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers. (2007). https://pubmed.ncbi.nlm.nih.gov/17536819/ DOI: 10.1021/jf063624i
- tissue_or_cell_type
- Intestinal epithelial monolayer
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 611–622
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Caco-2 intestinal transport model · source_derived_draft · unverified_draft
### ala-intestinal-ph-transport Caco-2 lipoic-acid transport was energy dependent, increased at acidic pH and was inhibited by tested monocarboxylates. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Absorption behavior depended on acidity and competing molecules in this cell model. organism: Human cell line tissue_or_cell_type: Intestinal epithelial monolayer experimental_model: Caco-2 intestinal transport model limitations: Cell model suggests proton-linked monocarboxylate transport but does not identify a specific SLC16 isoform or quantify whole-person absorption. exposure: Lipoic acid transport across pH and competing-monocarboxylate conditions evidence_span: {"source_cache": "artifacts/ala-research/17536819.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d777a0163a5cb3c8de0edf282cca050a720098f5ee7b0f4e22f9a0b3275c5b7c", "start_char": 0, "end_char": 863, "text_sha256": "d777a0163a5cb3c8de0edf282cca050a720098f5ee7b0f4e22f9a0b3275c5b7c"} [ala-p17536819] Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers. (2007). https://pubmed.ncbi.nlm.nih.gov/17536819/ DOI: 10.1021/jf063624i
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.