Component
Intestinal failure classification in established short-bowel syndrome
Intestinal failure classification in established short-bowel syndrome. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A 20 micromolar threshold classified permanent intestinal failure with 92% sensitivity and 90% specificity in this cohort.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/citrulline-research/11113071.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246", "start_char": 0, "end_char": 2196, "text_sha256": "e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246"}
- experimental_model
- Observational diagnostic study after intestinal adaptation
- exposure
- At least two years after final bowel reconstruction
- limitations
- The 20 micromolar classifier belongs to this cohort and indication, not a universal dietary deficiency cutoff.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human, 57 adults with short-bowel syndrome and 51 controls
- plain_language
- This is a study-specific diagnostic result, not a target blood level for everyone.
- primary_references
- [citrulline-p11113071] Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/11113071/ DOI: 10.1053/gast.2000.20227
- tissue_or_cell_type
- Postabsorptive blood and intestinal absorptive function
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 983–994
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Observational diagnostic study after intestinal adaptation · source_derived_draft · unverified_draft
### citrulline-short-bowel-classifier A 20 micromolar threshold classified permanent intestinal failure with 92% sensitivity and 90% specificity in this cohort. Condition category: biomarker_context nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: This is a study-specific diagnostic result, not a target blood level for everyone. organism: Human, 57 adults with short-bowel syndrome and 51 controls tissue_or_cell_type: Postabsorptive blood and intestinal absorptive function experimental_model: Observational diagnostic study after intestinal adaptation limitations: The 20 micromolar classifier belongs to this cohort and indication, not a universal dietary deficiency cutoff. exposure: At least two years after final bowel reconstruction evidence_span: {"source_cache": "artifacts/citrulline-research/11113071.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246", "start_char": 0, "end_char": 2196, "text_sha256": "e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246"} [citrulline-p11113071] Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/11113071/ DOI: 10.1053/gast.2000.20227
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.