Component
Intestinal creatine transporter expression
Intestinal creatine transporter expression. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Intestinal CRT transcript expression was lower in the Crohn disease and ulcerative colitis biopsy groups than in controls.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/32433978.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887", "start_char": 0, "end_char": 2283, "text_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887"}
- experimental_model
- Transporter manipulation, intestinal organoids and human biopsy comparison
- exposure
- CRT knockdown/overexpression; transporter-deficient organoids; 30 Crohn disease, 27 ulcerative colitis and 30 control biopsies
- limitations
- Causal epithelial experiments and observational human expression findings are distinct; no human creatine treatment outcome was tested.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- Humans
- plain_language
- The human tissue comparison found an association; it did not show that reduced creatine intake caused bowel disease.
- primary_references
- [creatine-p32433978] Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. (2020). https://pubmed.ncbi.nlm.nih.gov/32433978/ DOI: 10.1053/j.gastro.2020.05.033
- tissue_or_cell_type
- Intestinal biopsies
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 672–683
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter manipulation, intestinal organoids and human biopsy comparison · source_derived_draft · unverified_draft
### creatine-ibd-crt-expression Intestinal CRT transcript expression was lower in the Crohn disease and ulcerative colitis biopsy groups than in controls. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The human tissue comparison found an association; it did not show that reduced creatine intake caused bowel disease. organism: Humans tissue_or_cell_type: Intestinal biopsies experimental_model: Transporter manipulation, intestinal organoids and human biopsy comparison limitations: Causal epithelial experiments and observational human expression findings are distinct; no human creatine treatment outcome was tested. exposure: CRT knockdown/overexpression; transporter-deficient organoids; 30 Crohn disease, 27 ulcerative colitis and 30 control biopsies evidence_span: {"source_cache": "artifacts/creatine-research/32433978.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887", "start_char": 0, "end_char": 2283, "text_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887"} [creatine-p32433978] Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. (2020). https://pubmed.ncbi.nlm.nih.gov/32433978/ DOI: 10.1053/j.gastro.2020.05.033
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.