{"id":"409b1fb0-3be0-5cd5-b401-3a6dc688f7af","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-ibd-crt-expression","predicate":"had_lower_expression_in_ibd_as","statement":"Intestinal CRT transcript expression was lower in the Crohn disease and ulcerative colitis biopsy groups than in controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5486c7bc-3556-5eed-92a3-64f2a94dc699","mechanism_event_label":"The human tissue comparison found an association; it did not show that reduced creatine intake caused bowel disease.","subject":{"id":"75fe55a3-ff87-5cbd-bb76-e808421fa627","slug":"slc6a8","display_name":"Human creatine transporter CRT / SLC6A8","entity_type_key":"protein"},"object":{"id":"76f5367d-1aea-538c-8a73-ce7449f30b2a","slug":"intestinal-crt-expression","display_name":"Intestinal creatine transporter expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5486c7bc-3556-5eed-92a3-64f2a94dc699","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-ibd-crt-expression-event","event_type":"observed_intervention","label":"The human tissue comparison found an association; it did not show that reduced creatine intake caused bowel disease.","description":"Intestinal CRT transcript expression was lower in the Crohn disease and ulcerative colitis biopsy groups than in controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"75fe55a3-ff87-5cbd-bb76-e808421fa627","slug":"slc6a8","display_name":"Human creatine transporter CRT / SLC6A8","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"76f5367d-1aea-538c-8a73-ce7449f30b2a","slug":"intestinal-crt-expression","display_name":"Intestinal creatine transporter expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/32433978.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887\", \"start_char\": 0, \"end_char\": 2283, \"text_sha256\": \"1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transporter manipulation, intestinal organoids and human biopsy comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"CRT knockdown/overexpression; transporter-deficient organoids; 30 Crohn disease, 27 ulcerative colitis and 30 control biopsies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Causal epithelial experiments and observational human expression findings are distinct; no human creatine treatment outcome was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The human tissue comparison found an association; it did not show that reduced creatine intake caused bowel disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p32433978] Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. (2020). https://pubmed.ncbi.nlm.nih.gov/32433978/ DOI: 10.1053/j.gastro.2020.05.033","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal biopsies","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"373a449e-87eb-511f-a4ec-f96d1715f000","evidence_kind":"source_excerpt","locator":"Lines 672-683","start_line":672,"end_line":683,"excerpt":"### creatine-ibd-crt-expression\nIntestinal CRT transcript expression was lower in the Crohn disease and ulcerative colitis biopsy groups than in controls.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The human tissue comparison found an association; it did not show that reduced creatine intake caused bowel disease.\norganism: Humans\ntissue_or_cell_type: Intestinal biopsies\nexperimental_model: Transporter manipulation, intestinal organoids and human biopsy comparison\nlimitations: Causal epithelial experiments and observational human expression findings are distinct; no human creatine treatment outcome was tested.\nexposure: CRT knockdown/overexpression; transporter-deficient organoids; 30 Crohn disease, 27 ulcerative colitis and 30 control biopsies\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/32433978.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887\", \"start_char\": 0, \"end_char\": 2283, \"text_sha256\": \"1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887\"}\n[creatine-p32433978] Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. 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