Component
Intestinal citrulline release
Intestinal citrulline release. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Hypoxia and/or inflammation did not reduce citrulline production during the six-hour human explant experiment.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/citrulline-research/34882863.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3971162e4b915e3dadb6408a84cf3558526ee837e3446dd61c831f076f3fd901", "start_char": 0, "end_char": 1801, "text_sha256": "3971162e4b915e3dadb6408a84cf3558526ee837e3446dd61c831f076f3fd901"}
- experimental_model
- Six-hour human duodenal explant experiment
- exposure
- Control, hypoxia, inflammation and combined exposure
- limitations
- Short ex-vivo exposure cannot explain all low citrulline in prolonged critical illness; increased utilization remains a proposed explanation.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human biopsies from 25 selected patients
- plain_language
- Low circulating citrulline during illness cannot automatically be attributed to shut-down intestinal production.
- primary_references
- [citrulline-p34882863] Regulation of citrulline synthesis in human enterocytes: Role of hypoxia and inflammation. (2022). https://pubmed.ncbi.nlm.nih.gov/34882863/ DOI: 10.1002/biof.1810
- tissue_or_cell_type
- Intestinal citrulline production
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 1022–1033
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-hour human duodenal explant experiment · source_derived_draft · unverified_draft
### citrulline-explant-production-null Hypoxia and/or inflammation did not reduce citrulline production during the six-hour human explant experiment. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low circulating citrulline during illness cannot automatically be attributed to shut-down intestinal production. organism: Human biopsies from 25 selected patients tissue_or_cell_type: Intestinal citrulline production experimental_model: Six-hour human duodenal explant experiment limitations: Short ex-vivo exposure cannot explain all low citrulline in prolonged critical illness; increased utilization remains a proposed explanation. exposure: Control, hypoxia, inflammation and combined exposure evidence_span: {"source_cache": "artifacts/citrulline-research/34882863.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3971162e4b915e3dadb6408a84cf3558526ee837e3446dd61c831f076f3fd901", "start_char": 0, "end_char": 1801, "text_sha256": "3971162e4b915e3dadb6408a84cf3558526ee837e3446dd61c831f076f3fd901"} [citrulline-p34882863] Regulation of citrulline synthesis in human enterocytes: Role of hypoxia and inflammation. (2022). https://pubmed.ncbi.nlm.nih.gov/34882863/ DOI: 10.1002/biof.1810
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.