Component
Intestinal alpha-tocopherol apical efflux
Transfer from intestinal epithelial cells back into apical acceptor micelles.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SR-BI antibody or BLT1 reduced RRR-alpha-tocopherol efflux from loaded Caco-2 TC7 cells into apical vitamin-free mixed micelles.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Preloaded Caco-2 TC7 monolayers
- exposure
- Tocopherol-preloaded cells; apical acceptor micelles; time-course Figure 4.
- limitations
- Apical return is distinct from basolateral secretion; acceptor availability affects the result.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- The same receptor also helped vitamin E leave toward the gut-facing side.
- primary_references
- [reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200
- tissue_or_cell_type
- Intestinal epithelial cell model
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 194–205
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Preloaded Caco-2 TC7 monolayers · source_derived_draft · unverified_draft
### ve-transport-scarb1-apical-efflux SR-BI antibody or BLT1 reduced RRR-alpha-tocopherol efflux from loaded Caco-2 TC7 cells into apical vitamin-free mixed micelles. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same receptor also helped vitamin E leave toward the gut-facing side. organism: Homo sapiens tissue_or_cell_type: Intestinal epithelial cell model experimental_model: Preloaded Caco-2 TC7 monolayers limitations: Apical return is distinct from basolateral secretion; acceptor availability affects the result. exposure: Tocopherol-preloaded cells; apical acceptor micelles; time-course Figure 4. cross_nutrient: false [reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.