{"id":"438e504d-f698-5e9d-8afa-65bf6666759b","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ve-transport-scarb1-apical-efflux","predicate":"supports_efflux","statement":"SR-BI antibody or BLT1 reduced RRR-alpha-tocopherol efflux from loaded Caco-2 TC7 cells into apical vitamin-free mixed micelles.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"abaa414e-60dc-5ee4-bdd2-d33cbb399f2e","mechanism_event_label":"The same receptor also helped vitamin E leave toward the gut-facing side.","subject":{"id":"e00491c3-4448-559c-9012-57f5ce969157","slug":"scarb1","display_name":"Scavenger receptor class B type 1 / SCARB1","entity_type_key":"protein"},"object":{"id":"a198ee03-89f3-5f70-808d-8653da384fcf","slug":"intestinal-alpha-tocopherol-apical-efflux","display_name":"Intestinal alpha-tocopherol apical efflux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"abaa414e-60dc-5ee4-bdd2-d33cbb399f2e","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ve-transport-scarb1-apical-efflux-event","event_type":"biochemical_relationship","label":"The same receptor also helped vitamin E leave toward the gut-facing side.","description":"SR-BI antibody or BLT1 reduced RRR-alpha-tocopherol efflux from loaded Caco-2 TC7 cells into apical vitamin-free mixed micelles.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e00491c3-4448-559c-9012-57f5ce969157","slug":"scarb1","display_name":"Scavenger receptor class B type 1 / SCARB1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a198ee03-89f3-5f70-808d-8653da384fcf","slug":"intestinal-alpha-tocopherol-apical-efflux","display_name":"Intestinal alpha-tocopherol apical efflux","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae6048a7-d112-5d3a-8e7c-ad5a152642f9","slug":"rrr-alpha-tocopherol","display_name":"RRR-alpha-tocopherol","entity_type_key":"small_molecule"},"role":"efflux_substrate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Preloaded Caco-2 TC7 monolayers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tocopherol-preloaded cells; apical acceptor micelles; time-course Figure 4.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Apical return is distinct from basolateral secretion; acceptor availability affects the result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same receptor also helped vitamin E leave toward the gut-facing side.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal epithelial cell model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7c54910f-d6a6-5105-8728-61adda80be5b","evidence_kind":"source_excerpt","locator":"Lines 194-205","start_line":194,"end_line":205,"excerpt":"### ve-transport-scarb1-apical-efflux\nSR-BI antibody or BLT1 reduced RRR-alpha-tocopherol efflux from loaded Caco-2 TC7 cells into apical vitamin-free mixed micelles.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The same receptor also helped vitamin E leave toward the gut-facing side.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal epithelial cell model\nexperimental_model: Preloaded Caco-2 TC7 monolayers\nlimitations: Apical return is distinct from basolateral secretion; acceptor availability affects the result.\nexposure: Tocopherol-preloaded cells; apical acceptor micelles; time-course Figure 4.\ncross_nutrient: false\n[reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200","model_system":"Preloaded Caco-2 TC7 monolayers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [reboul2006] Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. (2006). https://pubmed.ncbi.nlm.nih.gov/16380385/ DOI: 10.1074/jbc.m509042200","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}