Component
International normalized ratio / INR
International normalized ratio / INR. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MK-7 at 45 micrograms/day lowered mean INR and uncarboxylated factor II by about 40%; lower doses altered anticoagulation in some participants.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/k2-research/23530987.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af", "start_char": 0, "end_char": 1740, "text_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af"}
- experimental_model
- Sequential dose-response intervention during anticoagulation
- exposure
- Acenocoumarol followed by MK-7 10, 20 and 45 micrograms/day
- limitations
- Small pharmacological study; no dose here is a recommended safe self-adjustment. Drug was acenocoumarol, not warfarin.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 18 healthy adults; 15 attained target INR
- plain_language
- K2 is involved in clotting as well as extrahepatic functions.
- primary_references
- [k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203
- tissue_or_cell_type
- Coagulation, osteocalcin and MGP markers
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1046–1057
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential dose-response intervention during anticoagulation · source_derived_draft · unverified_draft
### k2-mk7-inr MK-7 at 45 micrograms/day lowered mean INR and uncarboxylated factor II by about 40%; lower doses altered anticoagulation in some participants. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: K2 is involved in clotting as well as extrahepatic functions. organism: 18 healthy adults; 15 attained target INR tissue_or_cell_type: Coagulation, osteocalcin and MGP markers experimental_model: Sequential dose-response intervention during anticoagulation limitations: Small pharmacological study; no dose here is a recommended safe self-adjustment. Drug was acenocoumarol, not warfarin. exposure: Acenocoumarol followed by MK-7 10, 20 and 45 micrograms/day evidence_span: {"source_cache": "artifacts/k2-research/23530987.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af", "start_char": 0, "end_char": 1740, "text_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af"} [k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.