Component
Insulin receptor tyrosine-kinase activity
Insulin receptor tyrosine-kinase activity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Added chromium oligopeptide enhanced insulin-stimulated receptor tyrosine-kinase activity by up to eightfold in rat adipocyte membrane fragments; no enhancement occurred without insulin.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/9109644.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "23e955cef071c135f3935f440f4e333d49f494f004ceb22574df717c86bb7283", "start_char": 0, "end_char": 939, "text_sha256": "23e955cef071c135f3935f440f4e333d49f494f004ceb22574df717c86bb7283"}
- experimental_model
- Isolated rat insulin receptor and adipocyte membrane kinase assays
- exposure
- Insulin activation with added low-molecular-weight chromium-binding material
- limitations
- Assay activity is distinct from proof of an endogenous human cofactor. The peptide preparation and its cellular origin remain disputed; chromium is not shown to be an obligatory catalytic metal of INSR.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Rat receptor; isolated chromium oligopeptide preparation
- plain_language
- The preparation amplified an existing insulin signal in this experiment; it did not replace insulin.
- primary_references
- [chromium-p9109644] Chromium oligopeptide activates insulin receptor tyrosine kinase activity. (1997). https://pubmed.ncbi.nlm.nih.gov/9109644/ DOI: 10.1021/bi963154t
- tissue_or_cell_type
- Purified receptor and membrane fragments
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 263–274
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated rat insulin receptor and adipocyte membrane kinase assays · source_derived_draft · unverified_draft
### chromium-chromodulin-kinase-amplification Added chromium oligopeptide enhanced insulin-stimulated receptor tyrosine-kinase activity by up to eightfold in rat adipocyte membrane fragments; no enhancement occurred without insulin. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The preparation amplified an existing insulin signal in this experiment; it did not replace insulin. organism: Rat receptor; isolated chromium oligopeptide preparation tissue_or_cell_type: Purified receptor and membrane fragments experimental_model: Isolated rat insulin receptor and adipocyte membrane kinase assays limitations: Assay activity is distinct from proof of an endogenous human cofactor. The peptide preparation and its cellular origin remain disputed; chromium is not shown to be an obligatory catalytic metal of INSR. exposure: Insulin activation with added low-molecular-weight chromium-binding material evidence_span: {"source_cache": "artifacts/chromium-research/9109644.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "23e955cef071c135f3935f440f4e333d49f494f004ceb22574df717c86bb7283", "start_char": 0, "end_char": 939, "text_sha256": "23e955cef071c135f3935f440f4e333d49f494f004ceb22574df717c86bb7283"} [chromium-p9109644] Chromium oligopeptide activates insulin receptor tyrosine kinase activity. (1997). https://pubmed.ncbi.nlm.nih.gov/9109644/ DOI: 10.1021/bi963154t
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.