Component
Insulin-binding autoantibodies
Insulin-binding autoantibodies. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The case carried HLA-DRB1*0406 and had marked hypoglycemia, providing genetic context for the observed insulin autoimmunity.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/17329919.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411", "start_char": 0, "end_char": 608, "text_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411"}
- experimental_model
- Insulin autoimmune syndrome case report
- exposure
- Lipoic-acid exposure preceding symptoms
- limitations
- Temporal case association; does not establish incidence, universal HLA susceptibility or a proved molecular antigen mechanism.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Human
- plain_language
- Susceptibility may matter, but one case cannot define everyone’s risk.
- primary_references
- [ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893
- tissue_or_cell_type
- 55-year-old person with hypoglycemia and insulin autoantibodies
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 1313–1324
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Insulin autoimmune syndrome case report · source_derived_draft · unverified_draft
### ala-ias-hla-context The case carried HLA-DRB1*0406 and had marked hypoglycemia, providing genetic context for the observed insulin autoimmunity. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Susceptibility may matter, but one case cannot define everyone’s risk. organism: Human tissue_or_cell_type: 55-year-old person with hypoglycemia and insulin autoantibodies experimental_model: Insulin autoimmune syndrome case report limitations: Temporal case association; does not establish incidence, universal HLA susceptibility or a proved molecular antigen mechanism. exposure: Lipoic-acid exposure preceding symptoms evidence_span: {"source_cache": "artifacts/ala-research/17329919.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411", "start_char": 0, "end_char": 608, "text_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411"} [ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893
Complete structured claim and evidence
Where it participates (unsigned role)
A reported patient developed hypoglycemia with high insulin autoantibodies after lipoic-acid exposure.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/17329919.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411", "start_char": 0, "end_char": 608, "text_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411"}
- experimental_model
- Insulin autoimmune syndrome case report
- exposure
- Lipoic-acid exposure preceding symptoms
- limitations
- Temporal case association; does not establish incidence, universal HLA susceptibility or a proved molecular antigen mechanism.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Human
- plain_language
- Rare immune-mediated hypoglycemia is different from ordinary insulin sensitization.
- primary_references
- [ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893
- tissue_or_cell_type
- 55-year-old person with hypoglycemia and insulin autoantibodies
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 1300–1311
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Insulin autoimmune syndrome case report · source_derived_draft · unverified_draft
### ala-insulin-autoimmune-case A reported patient developed hypoglycemia with high insulin autoantibodies after lipoic-acid exposure. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Rare immune-mediated hypoglycemia is different from ordinary insulin sensitization. organism: Human tissue_or_cell_type: 55-year-old person with hypoglycemia and insulin autoantibodies experimental_model: Insulin autoimmune syndrome case report limitations: Temporal case association; does not establish incidence, universal HLA susceptibility or a proved molecular antigen mechanism. exposure: Lipoic-acid exposure preceding symptoms evidence_span: {"source_cache": "artifacts/ala-research/17329919.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411", "start_char": 0, "end_char": 608, "text_sha256": "966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411"} [ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.