{"id":"c7dc6431-fcfb-515b-8509-e3d540e2ec1d","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-ias-hla-context","predicate":"associated_with","statement":"The case carried HLA-DRB1*0406 and had marked hypoglycemia, providing genetic context for the observed insulin autoimmunity.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2e893ab2-7e29-53ec-8551-80489c2f7025","mechanism_event_label":"Susceptibility may matter, but one case cannot define everyone’s risk.","subject":{"id":"c3a68043-d8eb-5c31-b134-7ca74223ce0b","slug":"insulin-autoantibodies","display_name":"Insulin-binding autoantibodies","entity_type_key":"protein_complex"},"object":{"id":"b6c4e78e-0de2-5229-abcc-e03e8529179f","slug":"insulin-autoimmune-hypoglycemia","display_name":"Hypoglycemia associated with insulin autoimmunity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2e893ab2-7e29-53ec-8551-80489c2f7025","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-ias-hla-context-event","event_type":"observed_intervention","label":"Susceptibility may matter, but one case cannot define everyone’s risk.","description":"The case carried HLA-DRB1*0406 and had marked hypoglycemia, providing genetic context for the observed insulin autoimmunity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c3a68043-d8eb-5c31-b134-7ca74223ce0b","slug":"insulin-autoantibodies","display_name":"Insulin-binding autoantibodies","entity_type_key":"protein_complex"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6c4e78e-0de2-5229-abcc-e03e8529179f","slug":"insulin-autoimmune-hypoglycemia","display_name":"Hypoglycemia associated with insulin autoimmunity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ala-research/17329919.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411\", \"start_char\": 0, \"end_char\": 608, \"text_sha256\": \"966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Insulin autoimmune syndrome case report","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lipoic-acid exposure preceding symptoms","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Temporal case association; does not establish incidence, universal HLA susceptibility or a proved molecular antigen mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Susceptibility may matter, but one case cannot define everyone’s risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"55-year-old person with hypoglycemia and insulin autoantibodies","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8dfb652a-a6e9-5631-b1da-3992c70c4e8d","evidence_kind":"source_excerpt","locator":"Lines 1313-1324","start_line":1313,"end_line":1324,"excerpt":"### ala-ias-hla-context\nThe case carried HLA-DRB1*0406 and had marked hypoglycemia, providing genetic context for the observed insulin autoimmunity.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Susceptibility may matter, but one case cannot define everyone’s risk.\norganism: Human\ntissue_or_cell_type: 55-year-old person with hypoglycemia and insulin autoantibodies\nexperimental_model: Insulin autoimmune syndrome case report\nlimitations: Temporal case association; does not establish incidence, universal HLA susceptibility or a proved molecular antigen mechanism.\nexposure: Lipoic-acid exposure preceding symptoms\nevidence_span: {\"source_cache\": \"artifacts/ala-research/17329919.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411\", \"start_char\": 0, \"end_char\": 608, \"text_sha256\": \"966bd02f0d270b1b8ab0e6ae7403fdeb0360e0cc0ceca34dfa4eef3e30204411\"}\n[ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893","model_system":"Insulin autoimmune syndrome case report","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ala-p17329919] Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (2007). https://pubmed.ncbi.nlm.nih.gov/17329919/ DOI: 10.2169/internalmedicine.46.1893","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d8afa8c2-ced9-5b28-90ca-2ac120ec7202","stable_key":"import-5d8e27d8-6a74-5560-827f-3f90908bbc34","title":"Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"611da198ab85a272eb26b64ee330ef6d1a762853a8481f3191c4acfca9f3cf3d","revision_id":"618b4ce6-3157-5222-8325-408064be5ea5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}