Component
Myo-inositol 1,3,4-trisphosphate
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Purified calf-brain INPP1 showed cooperative magnesium dependence, with half-maximal stimulation near 0.3 mM.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Calf-brain enzyme purification and kinetics.
- limitations
- In-vitro cofactor concentration is not a human blood target.
- nutrient_topic
- Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
- plain_language
- A second recycling enzyme also depends on magnesium.
- primary_references
- Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. · 1987 · https://pubmed.ncbi.nlm.nih.gov/2824473/
Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 48–54
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Calf-brain enzyme purification and kinetics. · source_derived_draft · unverified_draft
## lithium-inpp1-magnesium A second recycling enzyme also depends on magnesium. Purified calf-brain INPP1 showed cooperative magnesium dependence, with half-maximal stimulation near 0.3 mM. Model: Calf-brain enzyme purification and kinetics. Limitations: In-vitro cofactor concentration is not a human blood target. Evidence access: Primary abstract Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. · 1987 · https://pubmed.ncbi.nlm.nih.gov/2824473/
Complete structured claim and evidenceLithium inhibited bovine INPP1 differently by substrate: Ki about 6 mM for Ins(1,4)P2 versus 0.5–1 mM for Ins(1,3,4)P3.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Purified calf-brain INPP1.
- limitations
- Do not substitute signaling IP3, Ins(1,4,5)P3, for the distinct Ins(1,3,4)P3 substrate.
- nutrient_topic
- Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
- plain_language
- The same enzyme can respond differently depending on its substrate.
- primary_references
- Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. · 1987 · https://pubmed.ncbi.nlm.nih.gov/2824473/
Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 56–62
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Purified calf-brain INPP1. · source_derived_draft · unverified_draft
## lithium-inpp1-substrate-specific The same enzyme can respond differently depending on its substrate. Lithium inhibited bovine INPP1 differently by substrate: Ki about 6 mM for Ins(1,4)P2 versus 0.5–1 mM for Ins(1,3,4)P3. Model: Purified calf-brain INPP1. Limitations: Do not substitute signaling IP3, Ins(1,4,5)P3, for the distinct Ins(1,3,4)P3 substrate. Evidence access: Primary abstract Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. · 1987 · https://pubmed.ncbi.nlm.nih.gov/2824473/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.