Influenza vaccine seroconversion: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Overall influenza antibody titers and seroconversion did not differ significantly between mixture and placebo groups.
L-Cystine plus L-theanine, study-specific combination → Influenza vaccine seroconversion source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/19149835.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8", "start_char": 0, "end_char": 1659, "text_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8"}
experimental_model
Randomized placebo-controlled vaccine response study
exposure
32 participants cystine-theanine; 33 placebo; 14 days supplementation
limitations
Overall negative result; subgroup observations require confirmation and do not establish universal benefit in low-protein states.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
65 elderly humans
plain_language
The main population result was negative.
primary_references
[theanine-p19149835] Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. (2008). https://pubmed.ncbi.nlm.nih.gov/19149835/ DOI: 10.1111/j.1447-0594.2008.00483.x
tissue_or_cell_type
Influenza hemagglutination-inhibition and seroconversion
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 822–833
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled vaccine response study · source_derived_draft · unverified_draft
### theanine-vaccine-overall-null Overall influenza antibody titers and seroconversion did not differ significantly between mixture and placebo groups. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The main population result was negative. organism: 65 elderly humans tissue_or_cell_type: Influenza hemagglutination-inhibition and seroconversion experimental_model: Randomized placebo-controlled vaccine response study limitations: Overall negative result; subgroup observations require confirmation and do not establish universal benefit in low-protein states. exposure: 32 participants cystine-theanine; 33 placebo; 14 days supplementation evidence_span: {"source_cache": "artifacts/theanine-research/19149835.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8", "start_char": 0, "end_char": 1659, "text_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8"} [theanine-p19149835] Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. (2008). https://pubmed.ncbi.nlm.nih.gov/19149835/ DOI: 10.1111/j.1447-0594.2008.00483.x
Complete structured claim and evidence
Higher H1N1 seroconversion was reported in low-total-protein and low-hemoglobin subgroups receiving the mixture.
L-Cystine plus L-theanine, study-specific combination → Influenza vaccine seroconversion source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/19149835.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8", "start_char": 0, "end_char": 1659, "text_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8"}
experimental_model
Randomized placebo-controlled vaccine response study
exposure
32 participants cystine-theanine; 33 placebo; 14 days supplementation
limitations
Overall negative result; subgroup observations require confirmation and do not establish universal benefit in low-protein states.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
65 elderly humans
plain_language
A subgroup signal can guide another study; it does not overturn the overall null result.
primary_references
[theanine-p19149835] Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. (2008). https://pubmed.ncbi.nlm.nih.gov/19149835/ DOI: 10.1111/j.1447-0594.2008.00483.x
tissue_or_cell_type
Exploratory low-total-protein or low-hemoglobin subgroups
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 835–846
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled vaccine response study · source_derived_draft · unverified_draft
### theanine-vaccine-subgroup Higher H1N1 seroconversion was reported in low-total-protein and low-hemoglobin subgroups receiving the mixture. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A subgroup signal can guide another study; it does not overturn the overall null result. organism: 65 elderly humans tissue_or_cell_type: Exploratory low-total-protein or low-hemoglobin subgroups experimental_model: Randomized placebo-controlled vaccine response study limitations: Overall negative result; subgroup observations require confirmation and do not establish universal benefit in low-protein states. exposure: 32 participants cystine-theanine; 33 placebo; 14 days supplementation evidence_span: {"source_cache": "artifacts/theanine-research/19149835.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8", "start_char": 0, "end_char": 1659, "text_sha256": "a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8"} [theanine-p19149835] Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. (2008). https://pubmed.ncbi.nlm.nih.gov/19149835/ DOI: 10.1111/j.1447-0594.2008.00483.x
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Influenza vaccine seroconversion