{"id":"93dba13b-256d-59aa-bfca-71c4ac3c35b7","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-vaccine-overall-null","predicate":"did_not_significantly_improve_overall","statement":"Overall influenza antibody titers and seroconversion did not differ significantly between mixture and placebo groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3941fec7-4534-56e1-978e-37913c98e83a","mechanism_event_label":"The main population result was negative.","subject":{"id":"6568c0b0-849d-5df3-8c6c-0c7565063844","slug":"cystine-theanine-combination","display_name":"L-Cystine plus L-theanine, study-specific combination","entity_type_key":"chemical_species"},"object":{"id":"0b99631e-aa75-5360-aa8f-f3b5c6fbdad8","slug":"influenza-vaccine-seroconversion","display_name":"Influenza vaccine seroconversion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3941fec7-4534-56e1-978e-37913c98e83a","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-vaccine-overall-null-event","event_type":"observed_intervention","label":"The main population result was negative.","description":"Overall influenza antibody titers and seroconversion did not differ significantly between mixture and placebo groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6568c0b0-849d-5df3-8c6c-0c7565063844","slug":"cystine-theanine-combination","display_name":"L-Cystine plus L-theanine, study-specific combination","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0b99631e-aa75-5360-aa8f-f3b5c6fbdad8","slug":"influenza-vaccine-seroconversion","display_name":"Influenza vaccine seroconversion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/19149835.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8\", \"start_char\": 0, \"end_char\": 1659, \"text_sha256\": \"a45aa5961c392e87f67d397ff9637dc5d65457d06397de0aaa5712c4daf00cf8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled vaccine response study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"32 participants cystine-theanine; 33 placebo; 14 days supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Overall negative result; subgroup observations require confirmation and do not establish universal benefit in low-protein states.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"65 elderly humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The main population result was negative.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p19149835] Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. 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