Component
NF-kappa-B reporter activity under influenza or cytokine stimulation
Reporter readout in a stably transfected line.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lariciresinol-4-O-β-D-glucopyranoside attenuated NF-κB activation in a reporter cell line and reduced influenza-induced cytokine production in lung epithelial cells.
Experimental context and source evidence
- duration
- Not stated here
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- HEK-293 cells stably carrying an NF-κB responsive firefly luciferase reporter, and A549 cells infected with influenza A virus
- exposure
- Lariciresinol-4-O-β-D-glucopyranoside isolated from the root of Isatis indigotica
- limitations
- A reporter readout rather than a direct measurement on any NF-κB subunit; no inhibitory concentration for the reporter is given.
- organism
- HEK-293 cells stably carrying an NF-κB responsive firefly luciferase reporter, and A549 cells infected with influenza A virus
- plain_language
- Lariciresinol-4-O-β-D-glucopyranoside attenuated NF-κB activation in a reporter cell line and reduced influenza-induced cytokine production in lung epithelial cells.
- primary_references
- Lariciresinol-4-O-β-D-glucopyranoside from the root of Isatis indigotica inhibits influenza A virus-induced pro-inflammatory response. (2015). https://pubmed.ncbi.nlm.nih.gov/26320688/ DOI: 10.1016/j.jep.2015.08.037
- route
- In vitro
- tissue
- NF-κB reporter activity and cytokine output
Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22) · lines 110–119
Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## glucoside-lowers-influenza-induced-nf-kb-activation Lariciresinol-4-O-β-D-glucopyranoside attenuated NF-κB activation in a reporter cell line and reduced influenza-induced cytokine production in lung epithelial cells. Model/species: HEK-293 cells stably carrying an NF-κB responsive firefly luciferase reporter, and A549 cells infected with influenza A virus Tissue/system: NF-κB reporter activity and cytokine output Exposure: Lariciresinol-4-O-β-D-glucopyranoside isolated from the root of Isatis indigotica Route: In vitro Duration: Not stated here Limits: A reporter readout rather than a direct measurement on any NF-κB subunit; no inhibitory concentration for the reporter is given. Primary reference: Lariciresinol-4-O-β-D-glucopyranoside from the root of Isatis indigotica inhibits influenza A virus-induced pro-inflammatory response. (2015). https://pubmed.ncbi.nlm.nih.gov/26320688/ DOI: 10.1016/j.jep.2015.08.037 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.