Component
Reported infant regurgitation improvement
Independent substance, clinical endpoint or measured readout; study context is retained with each finding.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Regurgitation improvement was reported in 69% versus 29% (P=0.003).
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- experimental_model
- Double-blind randomized trial: 79 referred infants younger than eight months with plasma total homocysteine at least 6.5 micromol/L, from 105 assessed.
- exposure
- One 400-microgram intramuscular hydroxocobalamin injection (42 infants) versus sham injection (37); one-month follow-up.
- limitations
- Parental symptom report in a selected short trial; does not identify the molecular gut mechanism.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- Feeding-related symptoms also improved more often in the intervention group.
- primary_references
- [b12-torsvik2013] Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study (2013). https://pubmed.ncbi.nlm.nih.gov/24025626/ DOI: 10.3945/ajcn.113.061549
- tissue_or_cell_type
- Human blood or whole-person endpoints
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1758–1768
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized trial: 79 referred infants younger than eight months with plasma total homocysteine at least 6.5 micromol/L, from 105 assessed. · source_derived_draft · unverified_draft
### b12-infant-regurgitation-response Regurgitation improvement was reported in 69% versus 29% (P=0.003). Condition category: biomarker_context nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Feeding-related symptoms also improved more often in the intervention group. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Double-blind randomized trial: 79 referred infants younger than eight months with plasma total homocysteine at least 6.5 micromol/L, from 105 assessed. limitations: Parental symptom report in a selected short trial; does not identify the molecular gut mechanism. exposure: One 400-microgram intramuscular hydroxocobalamin injection (42 infants) versus sham injection (37); one-month follow-up. [b12-torsvik2013] Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study (2013). https://pubmed.ncbi.nlm.nih.gov/24025626/ DOI: 10.3945/ajcn.113.061549
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.